化合物详情

CAS6754-13-8

分子式C15H18O4

分子量262.3 g/mol g/mol

非危品

Helenalin is a sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer). It has a role as a metabolite, an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is an organic heterotricyclic compound, a secondary alcohol, a gamma-lactone, a sesquiterpene lactone and a cyclic ketone.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Natural Pollution Sources

HELENIUM MICROCEPHALUM (SMALLHEAD SNEEZEWEED) IS...VERY TOXIC, PARTICULARLY IN THE FLOWERING STAGE. THE TOXIC PRINCIPLE IS NOW BELIEVED TO BE A SESQUITERPENE, HELENALIN.

Adverse Effects

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Human Toxicity Excerpts

HELENIUM MICROCEPHALUM (SMALLHEAD SNEEZEWEED) IS...VERY TOXIC, PARTICULARLY IN THE FLOWERING STAGE. THE TOXIC PRINCIPLE IS NOW BELIEVED TO BE A SESQUITERPENE, HELENALIN.

Non-Human Toxicity Excerpts

THE ORAL LD50 OF HELENALIN FOR 5 MAMMALIAN SPECIES (SHEEP, HAMSTERS, RABBITS, RATS, MICE) WAS BETWEEN 85-150 MG/KG.