化合物详情

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

IN ... MAN ... SYSTEMIC SIGNS OF TOXICITY PRECEDE BLOOD CHANGES, WHICH ARE USUALLY INCIDENTAL TO MAJOR CAUSE OF DEATH, ACUTE RENAL FAILURE. PROBABLY ... CHLORATE ... /IS/ DIRECT NEPHROTOXIN, BUT RENAL LESION IS ... AGGRAVATED BY INTRAVASCULAR HEMOLYSIS. /CHLORATE SALTS/

Although the cause of death following chlorate ingestion appears to be the tissue anoxia resulting from methemoglobinemia, the rate of methemoglobin formation is relatively slow & other signs usually precede cyanosis & dyspnea. These include staggering, purging, evidence of abdominal pain, hemoglobinuria, & hematuria. In acute chlorate poisoning, death may occur suddenly, without development of obvious clinical signs. /Chlorates & hypochlorites/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Treat seizures with diazepam (Valium) ... Use proparacaine hydrochloride to assist eye irrigation ... /Chlorates and related compounds/