化合物详情

CAS317-66-8

分子量823.600 g/mol g/mol

非危品

Propionyl-CoA is an acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of propionic acid. It has a role as a metabolite, a mouse metabolite and an Escherichia coli metabolite. It is functionally related to a coenzyme A and a propionic acid. It is a conjugate acid of a propionyl-CoA(4-).

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Symptoms

Propionic acidemia is characterized almost immediately in newborns. Symptoms include poor feeding, vomiting, dehydration, acidosis, low muscle tone (hypotonia), seizures, and lethargy. The effects of propionic acidemia quickly become life-threatening. (Wikipedia)

Treatment

The carnitine deficiency associated with propionic acuduria demands supplementation of free carnitine above the normal dietary intake to continue to remove (detoxify) the accumulating organic acids.

Health Effects

Propionic acidemia presents in the early neonatal period with progressive encephalopathy. Death can occur quickly, due to secondary hyperammonemia, infection, cardiomyopathy, or basal ganglial stroke. (Wikipedia)

Toxicity Summary

In propionic aciduria, propionyl CoA accumulates within the mitochondria in massive quantities; free carnitine is then esterified, creating propionyl carnitine, which is then excreted in the urine. Because the supply of carnitine in the diet and from synthesis is limited, such patients readily develop carnitine deficiency as a result of the increased loss of acylcarnitine derivatives.

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).