化合物详情

Pesticide Ecotoxicity Data from EPA: 46

LD50 Honey bee >100 ug/bee /Conditions of bioassay not specified./

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), thiazopyr, which has a vapor pressure of 2.25X10-6 mm Hg at 25 °C (2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase thiazopyr is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 31 hours(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC), that was derived using a structure estimation method(3). Particulate-phase thiazopyr may be removed from the air by wet and dry deposition(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for thiazopyr can be estimated to be 542,000(SRC). According to a classification scheme(2), this estimated Koc value suggests that thiazopyr is expected to be immobile in soil.

In aerobic soil metabolism studies(1), thiazopyr degraded with half-lives of 111 and 437 days in loam soil and in sandy loam soil, respectively.

A dynamic fish bioaccumulation study showed that thiazopyr should not bioconcentrate, with bioconcentration factors ranging from 11 to 400 for different fish tissue(1). According to a classification scheme(2), BCF values less than 30 are low and from 100 to 1,000 are high.

The Henry's Law constant for thiazopyr is estimated as 4.7X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 2.250X10-6 mm Hg at 25 °C(1), and water solubility, 2.5 mg/l(1). This Henry's Law constant indicates that thiazopyr is expected to volatilize slowly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 156 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 1,138 days(SRC).

The rate constant for the vapor-phase reaction of thiazopyr with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 31 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1).

Thiazopyr's production may result in its release to the environment through various waste streams; it's use as a herbicide(1) will result in its direct release to the environment(SRC).

Occupational exposure to thiazopyr may occur through inhalation of dust and dermal contact with this compound at workplaces where thiazopyr is produced or used. (SRC)

Thiazopyr's production may result in its release to the environment through various waste streams; it's use as a herbicide will result in its direct release to the environment. If released to air, a vapor pressure of 2.25X10-6 mm Hg at 25 °C indicates thiazopyr will exist in both the vapor and the particulate phases in the ambient atmosphere. Vapor-phase thiazopyr will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 31 hours. Particulate-phase thiazopyr will be removed from the atmosphere by wet and dry deposition. If released to soil, thiazopyr is expected to be immobile in soil based on an estimated Koc value of 542,000. In 14 field dissipation studies across the U.S., the vertical mov...

collection=toxvaldb&kind=^EL$

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

No indication of carcinogenicity to humans (not listed by IARC).

LD50 Rat dermal >5000 mg/kg

A mouse carcinogenicity study at doses of 0, 0.17, 1.6, 16.9, 66.3 or 128.4 mg/kg/day (males) & 0,0.24, 2.6, 26.8, 108.1 or 215.9 mg/kg/day (female) with a systemic NOEL of 0.1 mg/kg/day. The effects were hepatocellular hypertropy & amyloid deposition. At 66.3 mg/kg/day the same lesions plus increased liver weights, random & periportal hepatocellular vacuolation were observed. At 128.4 mg/kg/day the same lesions plus distended abdomen, slight incr in ALP, SGOT & SGPT, abnormal coloration & enlargement of liver, decr in absolute & relative spleen weights, incr in absolute & relative kidney weights, incr in eosinophilia in hepatocytes, kidney nephropathy & lymphocytic hyperplasia of the nesenteric lymph nodes were observed. There was no evidence of oncogenicity at any dose level. A 2 yr r...

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/