化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzyldimethylstearylammonium chloride, which has an estimated vapor pressure of 1.2X10-13 mm Hg at 25 °C(SRC), using a fragment constant estimation method(2), is expected to exist in the particulate phase in the ambient atmosphere. Particulate-phase benzyldimethylstearylammonium chloride may be removed from the air by wet and dry deposition(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for benzyldimethylstearylammonium chloride can be estimated to be 3X10+7(SRC). According to a classification scheme(2), this estimated Koc value suggests that benzyldimethylstearylammonium chloride is expected to be immobile in soil.

AEROBIC: Benzyldimethystearylammonium chloride did not degrade after 10 days using the MITI test(1). The SCAS method and the OECD Confirmatory test showed 94 and 95% degradation of benzyldimethylstearylammonium chloride, respectively(2).

An estimated BCF of 71 was calculated for benzyldimethylstearylammonium chloride(SRC), using a log Kow of 3.23(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

The Henry's Law constant for benzyldimethylstearylammonium chloride is estimated as 4.2X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that benzyldimethylstearylammonium chloride is expected to be essentially nonvolatile from water surfaces(2). Benzyldimethylstearylammonium chloride's estimated Henry's Law constant(1) indicates that volatilization from moist soil surfaces will not occur(SRC). Benzyldimethylstearylammonium chloride is not expected to volatilize from dry soil surfaces(SRC) based upon a an estimated vapor pressure of 1.2X10-13 mm Hg(SRC), determined from a fragment constant method(3).

Benzyldimethylstearylammonium chloride is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3) nor to directly photolyze due to the lack of absorption in the environmental UV spectrum (>290 nm).

Benzyldimethylstearylammonium chloride's production and use in contraceptive formulations(1), in industrial and institutional cleaners, various detergents, emulsion polymerization process, and paper and textile processing(2) may result in its release to the environment through various waste streams(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 25,059 workers (15,638 of these are female) are potentially exposed to benzyldimethylstearylammonium chloride in the US(1). Occupational exposure to benzyldimethylstearylammonium chloride may occur via dermal contact with this compound at workplaces where benzyldimethylstearylammonium chloride is produced or used(SRC). The general population may be exposed to benzyldimethylstearylammonium chloride by using consumer products containing benzyldimethylstearylammonium chloride(SRC).

Benzyldimethylstearylammonium chloride's production and use as in contraceptive formulations, in industrial and institutional cleaners, various detergents, emulsion polymerization process, and paper and textile processing may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 1.2X10-13 mm Hg at 25 °C indicates benzyldimethylstearylammonium chloride will exist solely in the particulate phase in the ambient atmosphere. Particulate-phase benzyldimethylstearylammonium chloride will be removed from the atmosphere by wet and dry deposition. If released to soil, benzyldimethylstearylammonium chloride is expected to have no mobility based upon an estimated Koc of 3X10+7. Volatilization from moist soil surfaces is not expect...

LC50 (rat) = 3,280 mg/m3/4h

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Poison by intraperitoneal route. Moderately toxic by ingestion. A human skin irritant and severe experimental eye irritant.

LD50 Guinea pig oral 500 mg/kg

CAPILLARY PERMEABILITY IN RABBIT AND MOUSE WAS INCREASED WHEN DODECYLDIMETHYLBENZYLAMMONIUM CHLORIDE WAS INTRACUTANEOUSLY INJECTED. THE PERMEABILITY THRESHOLDS WERE 0.01% AND 0.005% WHEN INJECTED INTO RABBIT AND MOUSE, RESPECTIVELY. THE PERMEABILITY THRESHOLD INCREASED 100-200-FOLD IN THE PRESENCE OF A KERATINOUS LAYER.