化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dilauryl thiodipropionate, which has an estimated vapor pressure of 3X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dilauryl thiodipropionate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7.4 hours(SRC), calculated from its rate constant of 5.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase dilauryl thiodipropionate may be removed from the air by wet or dry deposition(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dilauryl thiodipropionate can be estimated to be 9X10+6(SRC). According to a classification scheme(2), this estimated Koc value suggests that dilauryl thiodipropionate is expected to be immobile in soil.

AEROBIC: Dilauryl thiodipropionate, present at 100 mg/L, reached 57% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1); a theoretical BOD of 60% or higher indicates readily biodegradable(1). Although not classified as readily biodegradable, dilauryl thiodipropionate is estimated to be inherently biodegradable based on the data available(2).

An estimated BCF of 15 was calculated in fish for dilauryl thiodipropionate(SRC), using an estimated log Kow of 11.8(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for dilauryl thiodipropionate is estimated as 4X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that dilauryl thiodipropionate is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 21 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 160 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 60 years if adsorption...

The rate constant for the vapor-phase reaction of dilauryl thiodipropionate with photochemically-produced hydroxyl radicals has been estimated as 5.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7.4 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.077 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 2.8 years and 104 days at pH values of 7 and 8, respectively(SRC).

Dilauryl thiodipropionate's production and use as an antioxidant, additive for high-pressure lubricants and greases, plasticizer and softening agent, and antioxidant for edible fats and oils(1) may result in its release to the environment through various waste streams(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 18,006 workers (7,053 of these were female) were potentially exposed to dilauryl thiodipropionate in the US(1). Occupational exposure to dilauryl thiodipropionate may occur through dermal contact with this compound at workplaces where dilauryl thiodipropionate is produced or used. Dilauryl thiodipropionate's use as an antixidant in cosmetics(2) may expose the general population through dermal contact(SRC).

Dilauryl thiodipropionate's production and use as an antioxidant, additive for high-pressure lubricants and greases, plasticizer and softening agent, and antioxidant for edible fats and oils may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 3X10-8 mm Hg at 25 °C indicates dilauryl thiodipropionate will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase dilauryl thiodipropionate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 7.4 hours. Particulate-phase dilauryl thiodipropionate will be removed from the atmosphere by wet or dry deposition. If released to soil, dilauryl thiodipropi...

Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications

LD50 Mouse oral >2000 mg/kg bw

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ ADMIN OF 1000 MG/KG TO PREGNANT RABBITS FOR 13 CONSECUTIVE DAYS HAD NO EFFECT ON NIDATION OR ON MATERNAL OR FETAL SURVIVAL.

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...