化合物详情

LC50 Lepomis macrochirus (bluegill, length 33-75 mm) 11 mg/L/96 hr; static, 23 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methanesulfonyl chloride, which has an estimated vapor pressure of 3.1 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methanesulfonyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 150 days(SRC), calculated from its rate constant of 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of methanesulfonyl chloride can be estimated to be 6.1(SRC). According to a classification scheme(2), this estimated Koc value suggests that methanesulfonyl chloride is expected to have very high mobility in soil.

An estimated BCF of 1.9 was calculated for methanesulfonyl chloride(SRC), using an estimated log Kow of 1.3(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for methanesulfonyl chloride is estimated as 4.4X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that methanesulfonyl chloride is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 15 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 11 days(SRC). Methanesulfonyl chloride's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Methanesulfonyl chloride is expected to volatilize from dry soil surfaces(SRC) based upon an estimated va...

The rate constant for the vapor-phase reaction of methanesulfonyl chloride with photochemically-produced hydroxyl radicals has been estimated as 1.1X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 150 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Methanesulfonyl chloride hydrolyzes slowly in water(2). Methanesulfonyl chloride does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(3).

DRINKING WATER: Methanesulfonyl chloride was detected and identified as an ozonation byproduct in ozone treated water that was collected from Jefferson Parish, LA in January 1994, August 1994, May 1995, and September 1996(1).

The substance is harmful to aquatic organisms.

Methanesulfonyl chloride's production and use in flame-resistant products, as a stabilizer for liquid sulfur trioxide, as a biological chemical, as a chemical intermediate(1) in the photographic, fiber dye, agricultural, and pharmaceutical industries, a catalyst, curing agent, and chlorinating agent(2) may result in its release to the environment through various waste streams(SRC).

Methylsulfonyl chloride was detected in workplace air samples at a softwood and hardwood kraft pulp mill which utilized chlorine-containing bleaching agents. Six samples were positive with concentrations ranging from 2-20 ug/cu m, median was 6 ug/cu m(1) in the softwood bleaching plant. 34 samples were positive with concentrations ranging from 0.9 to 4.5 ug/cu m, median was 2.2 ug/cu m(1) in the hardwood bleaching plant.

Methylsulfonyl chloride's production and use in flame-resistant products, as a stabilizer for liquid sulfur trioxide, as a biological chemical, a chemical intermediate in the photographic, fiber dye, agricultural, and pharmaceutical industries, a catalyst, curing agent, and chlorinating agent may result in its release to the environment through various waste streams . If released to air, an estimated vapor pressure of 3.1 mm Hg at 25 °C indicates methanesulfonyl chloride will exist solely as a vapor in the atmosphere. Vapor-phase methanesulfonyl chloride will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 150 days. Methanesulfonyl chloride does not contain chromophores that absorb at wa...

Ingestion Exposure: See Inhalation.

LCLo = 620 mg/m3/6hr

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

The substance can be absorbed into the body by inhalation, by ingestion and through the skin.

/SIGNS AND SYMPTOMS/ Methanesulfonyl chloride is corrosive to eyes, skin, and mucous membranes.

LC50 Rat inhalation 25 ppm/4 hr

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously and consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... Administer atropine. Correct hypoxia before giving atropine ... Administer pralidoxime chloride (2 PAM). USE UND...