化合物详情

Pesticide Ecotoxicity Data from EPA: 10

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-hydroxymethyl-2-nitro-1,3-propanediol, which has an estimated vapor pressure of 3.2X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2-hydroxymethyl-2-nitro-1,3-propanediol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 33 days(SRC), calculated from its rate constant of 1.9X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase 2-hydroxymethyl-2-nitro-1,3-propanediol may be removed from...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-hydroxymethyl-2-nitro-1,3-propanediol can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-hydroxymethyl-2-nitro-1,3-propanediol is expected to have very high mobility in soil.

An estimated BCF of 1.3 was calculated for 2-hydroxymethyl-2-nitro-1,3-propanediol(SRC), using an estimated log Kow of -1.66(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for 2-hydroxymethyl-2-nitro-1,3-propanediol is estimated as 4.8X10-12 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2-hydroxymethyl-2-nitro-1,3-propanediol is expected to be essentially nonvolatile from moist soil and water surfaces(2). 2-Hydroxymethyl-2-nitro-1,3-propanediol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.2X10-7 mm Hg(SRC), determined from a fragment constant method(3).

The rate constant for the vapor-phase reaction of 2-hydroxymethyl-2-nitro-1,3-propanediol with photochemically-produced hydroxyl radicals has been estimated as 1.9X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 33 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Hydroxymethyl-2-nitro-1,3-propanediol has reported hydrolysis half-lives of stable days, 3.4 days and 2.4 days at pH values 5, 7 and 9, respectively(2). 2-Hydroxymethyl-2-nitro-1,3-propanediol decomposes to formaldehyde under alkaline conditions and at temperatures above 49 °C(3). 2-Hydroxymethyl-2-nitro-1,3-propanediol does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected...

2-Hydroxymethyl-2-nitro-1,3-propanediol's production and use as bacteriacide, in cutting oils and non-protein glue sizings(1) may result in its release to the environment through various waste streams(SRC). 2-Hydroxymethyl-2-nitro-1,3-propanediol's use as an inhibitor of bacterial growth in circulating industrial water systems(1) will result in its direct release to the environment(SRC).

Occupational exposure to 2-hydroxymethyl-2-nitro-1,3-propanediol may occur through dermal contact with this compound at workplaces where 2-hydroxymethyl-2-nitro-1,3-propanediol is produced or used. (SRC)

2-Hydroxymethyl-2-nitro-1,3-propanediol's production and use as bacteriacide, in cutting oils and non-protein glue sizings may result in its release to the environment through various waste streams. 2-Hydroxymethyl-2-nitro-1,3-propanediol's use as an inhibitor of bacterial growth in circulating industrial water systems will result in its direct release to the environment. If released to air, an estimated vapor pressure of 3.2X10-7 mm Hg at 25 °C indicates 2-hydroxymethyl-2-nitro-1,3-propanediol will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase 2-hydroxymethyl-2-nitro-1,3-propanediol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 33 days. Particulate...

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

/CASE REPORTS/ Two machinists were seen whose chronic hand dermatitis was explained by allergic sensitivity to a biocide, Tris Nitro (2-[hydroxymethyl]-2-nitro-1,3-propanediol).

LD50 Mouse oral 1900 mg/kg

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/