一键配货
化合物详情
CAS72599-27-0
分子式C10H21NO4
分子量219.28 g/mol g/mol
危化品
Miglustat is a hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. It has a role as an EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor and an anti-HIV agent. It is a member of piperidines and a tertiary amino compound. It is functionally related to a duvoglustat.
科学粮草官-词典编辑部，修订于：2026-07-06
Toxicity
ToxicityHepatotoxicity
Likelihood score: E (unlikely cause of clinically apparent liver injury).
Drug Induced Liver Injury
References: DOI:10.1016/j.drudis.2019.09.022
Effects During Pregnancy and Lactation
In humans, one report did not find that miglustat use in 5 males affected the production of sperm or their fertility. Animal studies in rats found that miglustat exposure lowered sperm production, which lowered fertility. However, this was not found in all animal studies; and some animal strains are more sensitive to this exposure. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy. For more information, please see the MotherToBaby fact sheet Paternal Exposures at https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/.
