selenic acid

短期高浓度硒口服暴露可能导致恶心、呕吐和腹泻。短时间暴露于高浓度元素硒或二氧化硒空气中可导致呼吸道刺激、支气管炎、呼吸困难和胃痛。对这些空气形式的长期暴露可导致呼吸道刺激、支气管痉挛和咳嗽。(L619)

毒性肺炎 - 因吸入金属烟雾或有毒气体和蒸汽引起的肺部炎症。

长期高浓度硒化合物口服暴露可导致一种称为硒中毒的疾病。硒中毒的主要症状是脱发、指甲脆性和神经系统异常（如四肢麻木和其他异常感觉）。动物研究表明，硒也可能影响精子产生和女性生殖周期。(L619)

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage...

3，对人致癌性无法分类。(L135)

/其他毒性信息/...通过皮肤吸收和摄入有毒。

慢性口服：0.005 mg/kg/天 (L134)

口服(L619)；吸入(L619)；皮肤接触(L619)

/遗传毒性/ 关于硒及其化合物致突变性的数据是不明确的。硒酸盐和亚硒酸盐(12微摩尔)在使用鼠肝均浆的反向突变试验中对鼠伤寒沙门氏菌菌株TA98、TA100和TA1537具有致突变性。在第二次试验中，硒酸钠具有致突变性，但亚硒酸钠没有；未报告使用的鼠伤寒沙门氏菌菌株。亚硒酸盐(亚硒酸钠和亚硒酸钠)在枯草芽孢杆菌菌株17A和45T中引起DNA损伤；然而，硒酸盐(硒酸和硒酸钠)在Rec试验中呈阴性。