化合物详情

The substance is harmful to aquatic organisms.

The following list includes some common operations in which exposure to selenium hexafluoride may occur: 1) Use as a gaseous electric insulator, 2) use during production of selenium hydroxide and hydrofluoric acid, selenium and nitrogen.

Short-term oral exposure to high concentrations of selenium may cause nausea, vomiting, and diarrhea. Brief exposures to high levels of elemental selenium or selenium dioxide in air can result in respiratory tract irritation, bronchitis, difficulty breathing, and stomach pains. Longer-term exposure to either of these air-borne forms can cause respiratory irritation, bronchial spasms, and coughing. (L619)

respiratory system

LCLo (rat) = 10 ppm/1H

Chronic oral exposure to high concentrations of selenium compounds can produce a disease called selenosis. The major signs of selenosis are hair loss, nail brittleness, and neurological abnormalities (such as numbness and other odd sensations in the extremities). Animal studies have shown that selenium may also affect sperm production and the female reproductive cycle. (L619)

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Oral (L619); inhalation (L619); dermal (L619)

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage...

Chronic Oral: 0.005 mg/kg/day (L134)

Oral Chronic Reference Dose Reference: CALEPA

3, not classifiable as to its carcinogenicity to humans. (L135)

/LABORATORY ANIMALS: Acute Exposure/ The acute toxicity of selenium hexfluoride /is/ ... about one-half that of ozone (Ct = 25 ppm-hr, represents an LC50 for small laboratory rodents).