化合物详情

Spiramide is an azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour. It has a role as a serotonergic antagonist and a dopaminergic antagonist. It is a member of piperidines, an aromatic ether, an azaspiro compound, an organofluorine compound and a tertiary amino compound.

科学粮草官-词典编辑部，修订于：2026-07-06