化合物详情

CAS114369-43-6

分子式C19H17ClN4

分子量336.818 g/mol

非危品

4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile is a member of the class of triazoles that is 1-chloro-4-(3-phenylpropyl)benzene substituted at position 3 of the propyl moiety by cyano and 1,2,4-triazol-1-ylmethyl groups. It is a nitrile, a member of triazoles and a member of monochlorobenzenes.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

EPA Ecotoxicity

Pesticide Ecotoxicity Data from EPA: 55

Effect Level

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Lethal Dose

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Toxicity Summary

Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also...

Lethal Concentration

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RAIS Toxicity Values

Oral Slope Factor Reference: OPP

Carcinogen Classification

No indication of carcinogenicity to humans (not listed by IARC).

Reference and Risk Values

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