化合物详情

A study of bioconcentration factors of environmental chemicals and their relationship to their lipophilic character was conducted. A bioconcentration factor was defined as the ratio of the steady state concentration of a chemical in the tissue of an organism to its concentration in water, using aquatic organisms such as algae or fish. Existing experimental data and data bases were reviewed. These were used to calculate bioconcentration factors on a lipid and a wet weight basis for ... polychlorinated biphenyls (PCBs) /including 3,4,3',4'-tetrachlorobiphenyl/. Lipophilicity of the compounds was assessed from published values of the n-octanol/water partition coefficients (Kow). ... Parabolic regression equations expressing logarithm bioconcentration factor lipid basis or logarithm bioconc...

... Following irradiation at 300 nm for 10 to 15 hr in both hexane and methanol /of 3,3',4,4'-TCB/ 3,4,4'-trichlorobiphenyl and 4,4'-dichlorobiphenyl were dechlorinated products ... trichloromethopybiphenyl was the methoxylated product.

/SRP 1988: THIS PCB FOUND IN AROCLORS 1242, 1248, 1254, AND 1260; CLOPHENS A40 AND 50; KANECHLORS 300, 400, 500, AND 600 COENTERS ... FROM MANUFACTURING PLANTS, DURING DESTRUCTION OF MANUFACTURED ARTICLES CONTAINING PCBS IN MUNICIPAL & INDUSTRIAL WASTE-DISPOSAL BURNERS, THROUGH GRADUAL WEAR & WEATHERING OF PCB-CONTAINING PRODUCTS, & THROUGH LEACHING FROM LAND-FILL DUMPS. /POLYCHLORINATED BIPHENYLS/

Chronic PCB exposure results in symptoms such as abdominal pain, nausea, vomiting, diarrhea, headache, dizziness, depression, nervousness, dermal and ocular lesions, fatigue, irregular menstrual cycles and a lowered immune response. (A3)

There are no specific treatments for PCB poisoning, since it is not usually recognized until after substantial chronic exposure. Only preventing further exposure and treating the observed symptoms can be done. Acute inhalation can be treated by administering oxygen. (L4)

LD50: 1010 mg/kg (Oral, Rat) (T14) LD50: 880 mg/kg (Intraperitoneal, Mouse) (T14)

The most common health effects of PCBs are skin conditions such as chloracne and rashes. Chronic PCB exposure has also been shown to cause liver, stomach and kidney, damage, jaundice, edema, anemia, changes in the immune system, behavioral alterations, and impaired reproduction. (L4)

NTP Carcinogen - Reasonably anticipated to be a human carcinogen.

Oral (L4); inhalation (L4); dermal (L4)

The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uterog...

Intermediate Oral: 0.03 ug/kg/day (L134)

Oral Slope Factor Reference: WHO/TEF

Food and Environmental Agents: Reported Sign or Symptom in Infant or Effect on Lactation: Polychlorinated biphenyls and polybrominated biphenyls: Lack of endurance, hypotonia, sullen, expressionless facies. /From Table 7/

1, carcinogenic to humans. (L135)

LD50 Guinea Pig oral 1 mg/kg

Fraction of Contaminant Absorbed Dermally from Soil: 0.14000000000000001

Fraction of Contaminant Absorbed Dermally from Soil: 0.14000000000000001