化合物详情

Vanadium tetrachloride is readily hydrolyzed(1). Vanadium tetrachloride forms acid mists in moist air; reacts with water to form corrosive fumes of HCl; can react violently or explosively with water(2). Vanadium tetrachloride decomposes by the action of light with the formation of chlorine gas(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,445 workers (230 of these are female) were potentially exposed to vanadium chloride in the US(1). Occupational exposure to vanadium tetrachloride may occur through inhalation and dermal contact with this compound at workplaces where vanadium tetrachloride is produced or used.

Inhalation of vanadium causes lung irritation, coughing, wheezing, chest pain, runny nose, and a sore throat. (L837)

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

LD50: 160 mg/kg (Oral, Rat) (T14)

Breathing high levels of vanadium affects the lungs, throat, and eyes. Ingestion of vanadium may cause kidney and liver damage, birth defects, or death. (L837)

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Oral (L837); inhalation (L837); dermal (L837)

Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. Vanadium is also believed to induce the production of reactive oxygen species. This may damage DNA and also cause oxidative stress, which can damage the reproductive system. Vanadium also inhibits protein tyrosine phosphatases, producing insulin-like effects. (L837, A247, A248, A249, A250, A251)

Acute Inhalation: 0.0002 mg/m3 (L134) Intermediate Oral: 0.003 mg/kg/day (L134)

/SIGNS AND SYMPTOMS/ Exposure may cause a green coating on the tongue.

No indication of carcinogenicity to humans (not listed by IARC).

LD50 Rat oral 160 mg/kg

/VETERINARY CASE REPORTS/ Accidental poisoning in a herd of cattle which had been grazing on pastures contaminated by vanadium tetrachloride has been reported ...

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . U...