化合物详情

ATMOSPHERIC FATE: Iron pentacarbonyl (Fe(CO)5), which has a vapor pressure of 21 mm Hg at 20 °C(1), and would be expected to exist as a vapor in the air(SRC). When exposed to light, iron pentacarbonyl is slowly converted to iron nonacarbonyl(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1822 workers (272 of these are female) were potentially exposed to iron carbonyl in the US(1). Occupational exposure to iron carbonyl may occur through inhalation and dermal contact with this compound at workplaces where iron carbonyl is produced or used(SRC).

Endogenous metals present in tobacco from agricultural practices have been purported to generate metal carbonyls in cigarette smoke. Transition metal catalysts, such as iron oxide, have been investigated for the reduction of carbon monoxide (CO) in cigarette smoke. These studies motivated the development of an analytical method to determine if iron pentacarbonyl [Fe(CO)(5)] is present in mainstream smoke from cigarette models having cigarette paper made with iron oxide. An FT-IR puff-by-puff method was developed and the detection limit was determined using two primary reference spectra from different sources to estimate the amount of Fe(CO)(5) present in a high-pressure steel cylinder of CO. We do not detect Fe(CO)(5) in a single 35 mL puff from reference cigarettes or from those cigare...

irritation eyes, mucous membrane, respiratory system; headache, dizziness, nausea, vomiting; fever, cyanosis, cough, dyspnea (breathing difficulty); liver, kidney, lung injury; degenerative changes in central nervous system

Eyes, respiratory system, central nervous system, liver, kidneys

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

inhalation, skin absorption, ingestion, skin and/or eye contact

IDENTIFICATION AND USE: Iron pentacarbonyl is a colorless to yellow, oily liquid. It is used to make finely divided iron, so-called carbonyl iron, which is used in the manufacture of powdered iron cores for high frequency coils used in the radio and television industry. It is also used as an antiknock agent in motor fuels, and as catalyst and reagent in organic reactions. HUMAN STUDIES: Potential symptoms of overexposure include irritation of eyes, mucous membranes, and respiratory system, as well as headache, dizziness, nausea, vomiting, fever, cyanosis, cough, and dyspnea. Degenerative CNS changes, as well as liver, kidney, and lung injury, may also occur. Death usually occurs in 4-11 days from exposure to lethal concentrations. Vapors of iron pentacarbonyl are extremely toxic and hav...

/OTHER TOXICITY INFORMATION/ Vapors of iron pentacarbonyl Fe(CO)5 are extremely toxic and have a strong effect on respiratory organs, and mucous membranes.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Rats (Alderley Park; n=4/sex/group) were exposed to pentacarbonyliron concentrations of... 57 mg/cu m (... 7 ppm ...), 5.5 hr/day, for ... 18 days ... . Exposure to 7 ppm did not result in signs of toxicity or in macroscopic changes in lungs, liver, kidneys, spleen, and adrenals (no more data/details presented).

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. ... Keep victim quiet and maintain normal body temperature. Medical observation is recommended for 24-48 hr after breathing overexposure, as pulmonary ed...