化合物详情

CAS15686-51-8

分子式C21H26ClNO

分子量343.89 g/mol g/mol

非危品

Clemastine is 2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions. It has a role as a H1-receptor antagonist, a muscarinic antagonist, an anti-allergic agent and an antipruritic drug. It is a N-alkylpyrrolidine and a member of monochlorobenzenes.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Hepatotoxicity

Drug Class: Antihistamines

Drug Induced Liver Injury

References: DOI:10.1016/j.drudis.2019.09.022

Effects During Pregnancy and Lactation

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.