化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol dinitrate, which has a vapor pressure of 5.9X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol dinitrate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.9 days(SRC), calculated from its rate constant of 3.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diethylene glycol dinitrate contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Photolysis hal...

The Koc of diethylene glycol dinitrate is estimated as 32(SRC), using a log Kow of 0.98(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diethylene glycol dinitrate is expected to have very high mobility in soil. The sorption partition coefficients, Kp, were calculated as 2.3 and 0.8 g/mL for EPA-5 sediment (33.6% sand, 31.0% clay, and 35.4% silt at pH 7.44) and EPA-18 sediment (34.6% sand, 39.5% clay, and 25.8% silt at pH 7.76), respectively; these correspond to Koc values of 100 and 120 g/mL, respectively(1).

ANAEROBIC: Using diethylene glycol dinitrate-contaminated water maintained under anaerobic conditions and enhanced with yeast, 100 ppm diethylene glycol dintrate was completely degraded in 35 days, with half-lives of 5 to 40 days reported, depending on the amount of organic nutrients or microbes present(1).

An estimated BCF of 3.2 was calculated in fish for diethylene glycol dinitrate(SRC), using a log Kow of 0.98(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for diethylene glycol dinitrate is estimated as 3.9X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 5.9X10-3 mm Hg(1), and water solubility, 3.9X10+3 mg/L(1). This Henry's Law constant indicates that diethylene glycol dinitrate is expected to be essentially nonvolatile from water surfaces(2). No loss (less than 5%) of diethylene glycol dinitrate from the aqueous phase was observed after 10 days of purging, indicating that volatilization will be extremely slow in the environment(1). Diethylene glycol dinitrate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

The photolysis half-lives of diethylene glycol dinitrate in surface waters under cloudless conditions at 40 deg N latitude for spring, summer, fall and winter were 19, 15, 33 and 59 days, respectively; average photolysis rates will decrease at depths below the surface. Photolysis products include nitrite, nitrate, and 2-hydroxyethyl nitratoacetate, with nitrate being the major inorganic degradation product of diethylene glycol dinitrate photolysis(1).

The substance is harmful to aquatic organisms.

Diethylene glycol dinitrate's production and use as plasticizer in solid rocket propellants(1), in low-freezing dynamites and some permissible explosives(2), and in low sensitivity gun propellants(3) may result in its release to the environment through various waste streams(SRC).

Occupational exposure to diethylene glycol dinitrate may occur through dermal contact with this compound at workplaces where diethylene glycol dinitrate is produced or used. Limited exposure to general population to diethylene glycol dinitrate may occur via inhalation. (SRC)

Diethylene glycol dinitrate's production and use as plasticizer in solid rocket propellants, in low-freezing dynamites and some permissible explosives, and in low sensitivity gun propellants may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 5.9X10-3 mm Hg at 25 °C indicates diethylene glycol dinitrate will exist solely as a vapor in the atmosphere. Vapor-phase diethylene glycol dinitrate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 4.9 days. Diethylene glycol dinitrate contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight. Photolysis half-lives ra...

Ingestion Exposure: See Inhalation.

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

/SIGNS AND SYMPTOMS/ Short term exposure: the substance may cause effects on the cardiovascular system, central nervous system and blood, resulting in impaired functions and the formation of methemoglobin. The effects may be delayed. Long term or repeated exposure: The substance may have effects on the cardiovascular system, resulting in cardiac disorders .

LD50 Mouse male oral gavage 1394 mg/kg

/LABORATORY ANIMALS: Acute Exposure/ A dose of 0.5 mL /diethylene gylcol dintrate/ (DEGDN) was applied to the clipped backs of New Zealand rabbits. After a 4 hr exposure, material was removed and the sites scored for irritation by the method of Draize. All animals showed a negative response during the 72 hr observation period. DEGDN was classified as nonirritating to skin.

Classification - D; not classifiable as to human carcinogenicity Basis - No human or animal carcinogenic studies found in the available literature. /Based on former classification system/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nitrates, nitrites, and related compounds/