化合物详情

ATMOSPHERIC FATE: C.I. Acid Red 114 is an ionic compound that will be essentially non-volatile in the environment(1,2). Therefore it is expected to exist solely in the particulate phase in the ambient atmosphere(SRC). Particulate-phase C.I. Acid Red 114 may be removed from the air by wet or dry deposition(SRC). C.I. Acid Red 114 absorbs light at 365 nm and 514 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

Due to its ionic nature, the retention of C.I. Acid Red 114 by ion-exchange processes(1), particularly on clay surfaces and adsorption at mineral surfaces such as geothite(2), indicates that it will be immobile in soil(SRC). It was noted during a biodegradation experiment that C.I. Acid Red 114 tended to adsorb onto sludge(3).

ANAEROBIC: Several laboratories studying the anaerobic degradation of C.I. Acid Red 114 obtained results of 33-90% degradation within 42 days using a sludge inoculum; some loss may be due to adsorption onto the sludge(1). C.I. Acid Red 114, present at 100 mg/L, was completely degraded within 7 days using an anaerobic sludge inoculum incubated at 35 °C. The main metabolites were 3,3'-dimethylbbenzidene and 4-methylbenzenesulphonic acid-(4'-aminophenyl) ester; 3,3'-dimethylbenzidene is classified as an A2 carcinogen(2).

Carp exposed to 0.2 mg/L and 0.02 mg/L of C.I. Acid Red 114 over an 8 week period had measured BCF values of 42-76 and 52-84, respectively(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

C.I. Acid Red 114 is an ionic compound(SRC). Therefore, it is not expected to undergo volatilization(1,2).

C.I. Acid Red 114 contains a sulfonic acid ester functional group(SRC), which may be susceptible to hydrolysis under environmental conditions(1). C.I. Acid Red 114 showed a light precipitate in water with a calcium concentration of 10-3 M(2). C.I. Acid Red 114 absorbs light at 365 nm and 514 nm(3) and therefore may be susceptible to direct photolysis by sunlight(SRC).

C.I. Acid Red 114's production and use as a dye(1,2) may result in its release to the environment through various waste streams(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 18,511 workers (352 of these were female) were potentially exposed to C.I. Acid Red 114 in the US(1). Occupational exposure to C.I. Acid Red 114 may occur through inhalation of dust and dermal contact with this compound at workplaces where C.I. Acid Red 114 is produced or used. Use data indicate that the general population may be exposed to C.I. Acid Red 114 via dermal contact by direct dyeing of wool and silk using consumer products containing C.I. Acid Red 114(SRC).

C.I. Acid Red 114's production and use as a dye may result in its release to the environment through various waste streams. If released to air, C.I. Acid Red 114 is expected to exist entirely in the particulate phase since it is an ionic compound. Particulate-phase C.I. Acid Red 114 will be removed from the atmosphere by wet or dry deposition. C.I. Acid Red 114 absorbs light at 365 nm and 514 nm and therefore will be susceptible to direct photolysis by sunlight. If released to soil, C.I. Acid Red 114 is expected to have no mobility based upon its ionic nature and its ability to absorb to clay and mineral surfaces. Volatilization from moist soil is not expected because the acid exists as an ion and ions do not volatilize. Utilizing the Japanese MITI test, 1% of the Theoretical BOD was re...

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

Summary: Under the conditions of these 2-year drinking water studies, there was clear evidence of carcinogenic activity of C.I. Acid Red 114 for male F344/N rats, as indicated by benign and malignant neoplasms of the skin, Zymbal's gland, and liver. Increased incidences of neoplasms of the oral cavity epithelium, adrenal gland, and lung may have been related to chemical administration. There was clear evidence of carcinogenic activity for female F344/N rats, as indicated by benign and malignant neoplasms of the skin, Zymbal's gland, clitoral gland, liver, oral cavity epithelium, small and large intestines, and lung. Increased incidences of mononuclear cell leukemia, mammary gland adenocarcinoma, and adrenal gland pheochromocytomas may have been related to chemical administration.

Evaluation: There is inadequate evidence in humans for the carcinogenicity of CI Acid Red 114. There is sufficient evidence in experimental animals for the carcinogenicity of CI Acid Red 114. Overall evaluation: CI Acid Red 114 is possibly carcinogenic to humans (Group 2B).

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...