化合物详情

Selenium sulfides are not very water soluble and therefore are relatively immobile in the environment(1).

According to the 2006 TSCA Inventory Update Report, the number of workers reasonably likely to be exposed in the industrial manufacturing, processing, and use of selenium disulfide is 1 to 99 persons; the data may be greatly underestimated(1).

Short-term oral exposure to high concentrations of selenium may cause nausea, vomiting, and diarrhea. Brief exposures to high levels of elemental selenium or selenium dioxide in air can result in respiratory tract irritation, bronchitis, difficulty breathing, and stomach pains. Longer-term exposure to either of these air-borne forms can cause respiratory irritation, bronchial spasms, and coughing. (L619)

LD50: 138 mg/kg (Oral, Rat) (T14)

Chronic oral exposure to high concentrations of selenium compounds can produce a disease called selenosis. The major signs of selenosis are hair loss, nail brittleness, and neurological abnormalities (such as numbness and other odd sensations in the extremities). Animal studies have shown that selenium may also affect sperm production and the female reproductive cycle. (L619)

Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

Oral (L619); inhalation (L619); dermal (L619)

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage...

Chronic Oral: 0.005 mg/kg/day (L134)

/CASE REPORTS/ ... A woman used selenium sulfide containing shampoo 2 or 3 times weekly for 8 months to cure excoriations of the scalp. One hour after the last wash, she developed tremor, abdominal pain, and occasionally vomited. She had garlic odor in her breath, and the urinary level of selenium 5 days later was 32 ug/mL.

3, not classifiable as to its carcinogenicity to humans. (L135)

LD50 Mouse oral 370 mg/kg