化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diisooctyl adipate, which has an estimated vapor pressure of 2.6X10-5 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase diisooctyl adipate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC), calculated from its estimated rate constant of 2.4X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Particulate-phase diisooctyl adipate may be removed from the air by wet and dry deposition(SRC). Diisooctyl adipate may also undergo direct photolysis in...

The Koc of diisooctyl adipate is estimated as 5X10+5(SRC), using an estimated log Kow of 8.1(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diisooctyl adipate is expected to be immobile in soil(SRC).

Diisooctyl adipate was degraded by pure bacterial and fungi cultures over 1 to 4 week incubation periods in shake flask experiments(1).

An estimated BCF of 60 was calculated for diisooctyl adipate(SRC), using an estimated log Kow of 8.1(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Henry's Law constant for diisooctyl adipate is estimated as 5.2X10-5 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that diisooctyl adipate is expected to volatilize from water surfaces(2). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 days if adsorption is neglected(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 32 days if adsorption is neglected(SRC). The volatilization half-life from a mo...

The rate constant for the vapor-phase reaction of diisooctyl adipate with photochemically-produced hydroxyl radicals has been estimated as 2.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 16 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.11 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 75 days and 2 years at pH values of 7 and 8, respectively(2). The expected products of hydrolysis are 6-methylheptanol and adipic acid. Diisooctyl adipate may also undergo direct photolysis in the environment since this compound contains a functional group that can absor...

Diisooctyl adipate's production and use as a plasticizer(1) may result in its release to the environment through various waste streams(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 5,147 workers (3,346 of these are female) are potentially exposed to diisooctyl adipate in the US(1). Occupational exposure to diisooctyl adipate may occur through inhalation and dermal contact with this compound at workplaces where diisooctyl adipate is produced or used(SRC).

Diisooctyl adipate's production and use as a plasticizer may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 2.6X10-5 mm Hg at 25 °C indicates diisooctyl adipate will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase diisooctyl adipate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 16 hours. Particulate-phase diisooctyl adipate will be removed from the atmosphere by wet and dry deposition. Diisooctyl adipate may undergo direct photolysis, but the kinetics of this reaction are unknown. If released to soil, diisooctyl adipate is expected to have no mobility based upon an est...

Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

LIKE DIOCTYL ADIPATE DI-ISO-OCTYL ADIPATE HAS A SLIGHT ACUTE & CHRONIC TOXICITY.

/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use propaparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/