化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-chloro-2-propanol, which has a vapor pressure of 4.9 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-chloro-2-propanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 days(SRC) from its estimated rate constant of 3.19X10-12 cu cm/molecule-sec at 25 °C(3).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1-chloro-2-propanol can be estimated to be about 2(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-chloro-2-propanol is expected to have very high mobility in soil.

An estimated BCF of 3 was calculated for 1-chloro-2-propanol(SRC), using an estimated log Kow of 0.53(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Henry's Law constant for 1-chloro-2-propanol is estimated as 1.7X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1-chloro-2-propanol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as approximately 150 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as approximately 3 years(SRC). 1-Chloro-2-propanol's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 1-chloro-2-propanol from dry soil surfaces may exist(...

The rate constant for the vapor-phase reaction of 1-chloro-2-propanol with photochemically-produced hydroxyl radicals has been estimated as 3.19X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A neutral first-order hydrolysis rate constant of 1.1X10-8 1/s corresponds to a half-life of 2 years a pH 7(2). By analogy to 1,3-dichloro-2-propanol which has a base-catalyzed second-order hydrolysis rate constant of 850 L/mole-hour(3), 1-chloro-2-propanol is expected to have a half-live of approximately 1 month at pH 8(4,SRC). 1-Chloro-2-propanol is not expected to directly photolyze due to the lack of absorption in the environmenta...

1-chloro-2-propanol was qualitatively detected as a volatile component of meat(1). 1-Chloro-2-propanol may be formed in foods (e.g., flour, pepper, cocoa, walnut meat, tapioca starch, glazed cherries, glazed citron, and dehydrated potato granules) fumigated with propylene oxide(2).

1-Chloro-2-propanol's production and use as a chemical intermediate(1) may result in its release to the environment through various waste streams.

Occupational exposure to 1-chloro-2-propanol may occur through inhalation and dermal contact with this compound at workplaces where 1-chloro-2-propanol is produced or used(SRC). The general population may be exposed to 1-chloro-2-propanol via food fumigated with propylene oxide(1).

1-Chloro-2-propanol's production and use as a chemical intermediate may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 4.9 mm Hg at 25 °C indicates 1-chloro-2-propanol will exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-chloro-2-propanol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5 days. If released to soil, 1-chloro-2-propanol is expected to have very high mobility based upon an estimated Koc of 2. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.7X10-6 atm-cu m/mole. 1-Chloro-2-propanol may potentially vola...

LC50 (rat) = 1000 ppm/4H

ACGIH Carcinogen - Not Classifiable.

Summary: Under the conditions of these 2-year drinking water studies, there was no evidence of carcinogenic activity of technical grade 1-chloro-2-propanol in male or female F344/N rats exposed to 150, 325, or 650 ppm. There was no evidence of carcinogenic activity of technical grade 1-chloro-2-propanol in male or female B6C3F1 mice exposed to 250, 500, or 1,000 ppm.

LD50 Rabbit dermal is 480 mg/kg, 0.48 mL/kg, and 0.5 g/kg

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam (Valium) ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider...