化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isophthalaldehyde, which has an estimated vapor pressure of 7.8X10-3 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isophthalaldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Based on structural analogy with o-phthalaldehyde, which has an absorption peak at 297 nm(3), isophthalaldehyde may be susceptible to...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of isophthalaldehyde can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that isophthalaldehyde is expected to have very high mobility in soil(SRC).

An estimated BCF of 4 was calculated in fish for isophthalaldehyde(SRC), using an estimated log Kow of 1.43(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Henry's Law constant for isophthalaldehyde is estimated as 3.4X10-8 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that isophthalaldehyde is expected to be essentially nonvolatile from water and moist soil surfaces(2). Isophthalaldehyde is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.8X10-3 mm Hg(SRC), determined from a fragment constant method(1).

The rate constant for the vapor-phase reaction of isophthalaldehyde with photochemically-produced hydroxyl radicals has been estimated as 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Isohthalaldehyde is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Based on structural analogy with o-phthalaldehyde, which has an absorption peak at 297 nm(3), isophthalaldehyde may be susceptible to direct photolysis by sunlight(SRC).

Isopthalaldehyde's production and use as a laboratory chemical(1) may result in its release to the environment through various waste streams(SRC).

Occupational exposure to isophthalaldehyde may occur through dermal contact with this compound at workplaces where isophthalaldehyde is produced or used. Use data indicate that the general population is not likely to be exposed to isophthalaldehyde. (SRC)

Isophthalaldehyde was detected in the emissions of canola cooking oil heated to 180 °C; concentration or emission rates were not reported(1).

Isophthalaldehyde's production and use as a laboratory chemical may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 7.8X10-3 mm Hg at 25 °C indicates isophthalaldehyde will exist solely as a vapor in the atmosphere. Vapor-phase isophthalaldehyde will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 11 hours. Based on structural analogy with o-phthalaldehyde, which has an absorption peak at 297 nm, isophthalaldehyde may be susceptible to direct photolysis by sunlight. If released to soil, isophthalaldehyde is expected to have very high mobility based upon an estimated Koc of 10. Volatilization from moist soil surfac...

IDENTIFICATION AND USE: m-Phthalaldehyde is a solid. It is used in the synthesis of binuclear ruthenium complex. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: There are no data available.

LD50 Mouse iv 100 mg/kg

/SRP:/ Advanced treatment: Consider Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Intubation should be considered at the first sign of upper airway obstruction caused by edema. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensiv...