化合物详情

This substance may be hazardous to the environment. Special attention should be given to soil organisms and aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

Arsenic chloride is produced from dry etching process of gallium arsenide wafers in chlorofluorocarbons and is contained in the wastes recovered from the vacuum system after the processing.

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

LD50: 145 mg/kg (Oral, Mouse) (L376)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)

ACGIH Carcinogen - Confirmed Human.

Oral (L2); inhalation (L2); dermal (L2)

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)

Exposure to arsenic trichloride, which has a vapor pressure at 25C sufficient to produce an air concn of 140,000 mg/m3, can cause irritation or ulceration on contact or may be absorbed through the skin, with fatal results ... .

WHO= 0.002 mg/kg /Inorganic arsenic cmpd, as As; from table/

1, carcinogenic to humans. (L135)

/Protect/ from exposure those individuals with diseases of skin, blood, liver, kidney, and central nervous system.

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of pulmonary edema. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Arsenic and related compounds/