化合物详情

Pesticide Ecotoxicity Data from EPA: 2

USDA APHIS Chemical Effects: collection=usda_chemeffect&query_type=synonym&query='^7778-44-1$'

ARSENIC WAS FOUND IN SIGNIFICANT CONCN IN DRAINAGE & RUNOFF WHERE CALCIUM ARSENATE HAD BEEN APPLIED. DRAINAGE FROM PLOTS PREVIOUSLY CORED FOR SOIL SAMPLES CONTAINED CONCN OF 8 PPM. AFTER HEAVY RAIN, SHORTLY AFTER APPLICATION, RUNOFF WAS AS GREAT AS 14 PPM.

This substance may be hazardous to the environment. Special attention should be given to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Workers engaged in manufacture, formulation, and application of pesticides containing calcium arsenate.

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels.

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

[lymphatic & lung cancer]

Eyes, respiratory system, liver, skin, central nervous system, lymphatic system

LD50: 20 mg/kg (Oral, Rat) (T14) LD50: 2400 mg/kg (Dermal, Rat) (T14)

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, especially in skin, liver, bladder and lung cancers. (T1, L20)

ACGIH Carcinogen - Confirmed Human.

Oral (L2); inhalation (L2); dermal (L2)

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)

Oral Slope Factor Reference: CALEPA

... OF COMPOUNDS TO WHICH SPRAYERS OF ORCHARDS ARE EXPOSED, CALCIUM ARSENATE IS THE MOST TOXIC; NEXT IS LEAD ARSENATE; & THIRD IS LEAD CARBONATE.

WHO= 0.002 mg/kg /Inorganic arsenic cmpd, as As; from table/

1, carcinogenic to humans. (L135)