化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dodecylbenzene, which has a vapor pressure of 5.1X10-5 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dodecylbenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 hours(SRC) from its estimated rate constant of 2X10-11 cu cm/molecule-sec at 25 °C(3). Particulate-phase dodecylbenzene may be removed from the air by wet and dry deposition(SRC).

The Koc of dodecylbenzene is estimated as 7.4X10+5(SRC), using a log Kow of 8.26(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dodecylbenzene is expected to be immobile in soil.

Various pure cultures of bacteria were shown to degrade dodecylbenzene(1,2). An activated sludge compound was shown to oxidize dodecylbenzene during a 180 hour incubation period(3). River die-away tests have shown linear alkylbenzenes are readily biodegradable, with half-lives of 4.8 and 10.1 days for C-12 isomers in river water(4).

An estimated BCF of 38 was calculated for dodecylbenzene(SRC), using a log Kow of 8.26(1), and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests bioconcentration in aquatic organisms is moderate. The BCF value of bluegill sunfish exposed to dodecylbenzene in a flow-through aquarium was 35(4).

The Henry's Law constant for dodecylbenzene is estimated as 0.13 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that dodecylbenzene is expected to volatilize rapidly from water surfaces(2), however adsorption may severely attenuate this process(SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 9 hours if adsorption is neglected(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 4 days if adsorption is neglected(SRC). The estimated volatilization half-life from a model pond is 21 years if adsorption is considered(3). Dodecylbenzene's Henry's L...

The rate constant for the vapor-phase reaction of dodecylbenzene with photochemically-produced hydroxyl radicals has been estimated as 2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 19 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Dodecylbenzene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2).

Dodecylbenzene was detected in rivers in Tokyo, Japan at concns of 0.037-14.42 ng/l(1). Dodecylbenzene was identified, not quantified, in the Besos and Llobregat Rivers, Spain near heavily industrialized areas(2,3).

Dodecylbenzene was detected in wastewater effluents in Tokyo, Japan at concns of 0.39-2.76 ng/l(1). Dodecylbenzene was detected in leachate from a surfactant manufacturing plant in Barcelona, Spain at concns of less than 0.5 ppm to 5 ppm(2).

Alkylbenzenes, including dodecylbenzene were detected in indoor air at concns of 100-200 ug/cu m in buildings with recently installed vinyl flooring(1).

Dodecylbenzene's production for use in detergents(1) may result in its release to the environment through various waste streams(SRC).

Dodecylbenzene was detected in suspended sediment from rivers in Tokyo, Japan at concns of 0.042-0.626 ug/g(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 21,273 workers (3,818 of these are female) are potentially exposed to dodecylbenzene in the US(1). Occupational exposure to dodecylbenzene may occur through inhalation and dermal contact with this compound at workplaces where dodecylbenzene is produced or used(SRC). The general population may be exposed to dodecylbenzene via dermal contact with this compound and other consumer products containing dodecylbenzene(SRC).

Dodecylbenzene's production for use in detergents may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 5.1X10-5 mm Hg at 25 °C indicates dodecylbenzene will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dodecylbenzene will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 19 hours. Particulate-phase dodecylbenzene will be removed from the atmosphere by wet and dry deposition. If released to soil, dodecylbenzene is expected to have no mobility based upon an estimated Koc of 7.4X10+5. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated...

Ingestion Exposure: Nausea.

IN GALAGOS GIVEN 0.2 ML OF 7,12-DMBA (2.5% SOLN IN ACETONE) IMMEDIATELY FOLLOWED BY 0.5 ML DDB APPLIED TO SAME AREA OF SKIN 3 TIMES/WK FOR 9 WK FOLLOWED BY DMBA & 100% DDB 2 TIMES/WK FOR 4 YR, BENIGN TUMORS (KERATOACANTHOMAS & PIGMENTED PAPILLOMA) WERE OBSERVED.

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

The substance can be absorbed into the body by ingestion.

LIQUID CAUSES MILD IRRITATION OF EYES & MAY CAUSE ALLERGENIC RESPONSE ON REPEATED CONTACT WITH SKIN. INGESTION CAUSES NAUSEA.

ORAL TOXICITY...IS VERY LOW; 5 G/KG SINGLE ORAL DOSE CAUSED NO DEATHS IN RATS.