化合物详情

LC50 (rat) = 1,500 mg/m3

Dermatotoxin - Skin burns.

The comparative toxicity of two chlorinated propene isomers, 1,2,3-trichloropropene (TRCP) and 1,1,2,3-tetrachloropropene (TECP), was investigated via subchronic oral admin to rats for 4 weeks. Test groups, each consisting of 5 male and 5 female rats, were exposed to 0, 3, 10, 30, 100 or 300 mg/kg/day TRCP or TECP by gavage. A separate corn oil control group was used for each chloropropene. While all rats of both sexes given 300 mg/kg/day TRCP died, only 1 female exposed to 300 mg/kg TECP died. Mean body weights were reduced in male rats given 100 mg/kg/day TRCP. With TECP, dose related reductions in mean body weight and food consumption were seen at 100 and 300 mg/kg/day. Moderate fatty changes in the livers of high dose TRCP treated rats which died during the first study week were pro...