化合物详情

Environmental fate of mercury and all its cmpd are relevant to mercuric oxide because of photodecomposition of mercuric oxide to mercury.

The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment.

Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5)

Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7)

LD50: 18 mg/kg (Oral, Rat) (L428)

Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7)

ACGIH Carcinogen - Not Classifiable.

Oral (L136); inhalation (L136); dermal (L136)

High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein...

Chronic Inhalation: 0.0002 mg/m3 (L134)

It is reported that employees at a mercuric oxide production facility associated with battery manufacture have exhibited a variety of symptoms: nervous system disorders, low sperm counts, and loss of weight. The employees may have been exposed to manganese, which may have augmented the reported clinical picture.

3, not classifiable as to its carcinogenicity to humans. (L135)

A toxicological study of poorly soluble mercury compounds, including mercuric iodide, mercuric ammonium chloride and mercuric oxide indicated that mercuric iodide was the most toxic compound. Acute toxicity study following administration via stomach and single inhalation exposure to rats showed they have approx similar toxicity.

Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient with severe pulmonary edema or respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Mercury and related compounds/