化合物详情

A SHORT TERM MAMMALIAN CARCINOGENICITY TEST SYSTEM IS PRESENTED IN WHICH AN IN VIVO APPLICATION IN RATS IS FOLLOWED AFTER 2 WEEKS BY AN IN VITRO CULTURE OF THE PERITONEAL CELLS. 2-ACETYLAMINOFLUORENE PROVED POSITIVE & 4-ACETYLAMINOFLUORENE WAS NEGATIVE. BOTH ANALOGS WERE APPLIED AT A SINGLE ORAL DOSE OF 50 MG/KG. 2-ACETYLAMINOFLUORENE WAS ALSO POSITIVE AT A DOSE OF 25 MG/KG CORRESPONDING TO 2.5% OF THE HIGHEST TOLERATED DOSE OF THIS CARCINOGEN. A HIGH STRUCTURE-RELATED SPECIFICITY OF TEST SYSTEM IS SUGGESTED.