化合物详情

Pesticide Ecotoxicity Data from EPA: 15

LC50; Species: Cyprinodon variegatus (Sheepshead minnow) >130 mg ae/L/96 hr

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), mefluidide, which has an estimated vapor pressure of 2.3X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase mefluidide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hours(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase mefluidide may be removed from the air by wet and dry deposition(SRC). Mefluidide contains chromophores that absorb at...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of mefluidide can be estimated to be 77(SRC). According to a classification scheme(2), this estimated Koc value suggests that mefluidide is expected to have high mobility in soil. The pKa of mefluidide is 4.78(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

AEROBIC: Mefluidide was reported to be rapidly degraded in soil with a half-life of <1 week, yielding the main metabolite 5-amino-2,4-dimethyltrifluoromethanesulfonanilide(1). A half-life of 12 days in aerobic soils was reported(2).

An estimated BCF of 10 was calculated for mefluidide(SRC), using a log Kow of 2.02(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for mefluidide is estimated as 1.3X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that the neutral form of mefluidide is expected to be essentially nonvolatile from water surfaces(2). A pKa of 4.78(3) indicates mefluidide will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process for the anionic form of mefluidide(SRC). Mefluidide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.4X10-8 mm Hg(SRC), determined from a fragment constant method(1).

The rate constant for the vapor-phase reaction of mefluidide with photochemically-produced hydroxyl radicals has been estimated as 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 0.64 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). It is generally resistant to hydrolysis and photolysis in sterile buffered solutions at pH 4-9(2). Mefluidide decomposes in aqueous solutions exposed to UV radiation(3). Photodegradation half-lives of 2-3 days in natural well water and 4.85 days on soil surfaces has been reported(2). Photodecomposition is reported to be rapid on wet soil surfaces, but water is critical for this reaction(4). Mefluidide contains chromophores that absorb at wa...

Mefluidide's production may result in its release to the environment through various waste streams; the use of its acid salts as plant growth regulators(1) will result in its direct release to the environment(SRC).

Occupational exposure to mefluidide may occur through inhalation of dust and dermal contact with this compound at workplaces where mefluidide is produced or used. Use data indicate the general population may be exposed to mefluidide when using consumer products contining this compound. (SRC)

Mefluidide's production may result in its release to the environment through various waste streams; the use of its acid salts as plant growth regulators will result in its direct release to the environment. If released to air, an estimated vapor pressure of 2.3X10-8 mm Hg at 25 °C indicates mefluidide will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase mefluidide will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2 hours. Particulate-phase mefluidide will be removed from the atmosphere by wet or dry deposition. Mufluidide contains chromophores that absorb at wavelengths >290 nm and, therefore, may be susceptible to direct photolysis by sunlight. If releas...

LC50 (rat) > 5,400 mg/m3

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

IDENTIFICATION AND USE: Mefluidide is a solid. It is plant growth regulator and herbicide. It is used to suppress seed heads and fruiting, as well as retarding growth to reduce mowing and trimming. It is also registered for growth control of low maintenance turf on rights-of-ways, airports, public and industrial sites. Mefluidide products can also be used on residential lawns. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: In rats and rabbits, critical effects of acute oral toxicity (doses of 100 mg/kg/day and above) were tremors, hunched posture, salivation, reduced body weight and body weight gain. Dogs are most sensitive to the effects of mefluidide, which occur at doses as low as 15 mg/kg/day in diets fed for one yr. In addition, dogs fed with mefluidide for one yr exhi...

Oral Chronic Reference Dose Reference: OPP

LD50 Rabbit (female) dermal > 4000 mg/kg

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or l...