化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bisphenol B, which has an estimated vapor pressure of 2.5X10-7 mm Hg at 25 °C((SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bisphenol B is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 8.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase bisphenol B may be removed from the air by wet and dry deposition(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of bisphenol B can be estimated to be 7.4X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that bisphenol B is expected to be immobile in soil. The estimated pKa of bisphenol B is 10.2(3), indicating that this compound will exist predominately in the non-ionized form in the environment(SRC); the anion form of bisphenol B in not expected to adsorb more strongly to soils containing organic carbon and clay than the neutral counterpart(3).

AEROBIC: In 22-day aerobic river die-away tests using several river water samples in 24 microcosms, bisphenol B showed no degradation in 12 microcosms and incomplete degradation in 12 microcosms. In anaerobic biodegradation tests using pond sediment, bisphenol B showed no degradation over the initial 60 days of incubation; after 84 days, approximately 60% of initial bisphenol B still remained(1).

An estimated BCF of 250 was calculated in fish for bisphenol B(SRC), using an estimated log Kow of 4.13(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

The Henry's Law constant for bisphenol B is estimated as 1.2X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that Bisphenol B is expected to be essentially nonvolatile from water surfaces(2). Bisphenol B's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Bisphenol B is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.5X10-7 mm Hg(SRC), determined from a fragment constant method(1).

The rate constant for the vapor-phase reaction of bisphenol B with photochemically-produced hydroxyl radicals has been estimated as 8.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Bisphenol B is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Phenols can undergo sensitized photo-oxidation in surface waters exposed to sunlight via reaction with hydroxyl and peroxy (RO2) radicals with half-lives on the order of days to weeks at the water surface(3); therefore, photo-oxidation may be an important fate process for bisphenol B in na...

Bisphenol B was detected in 9 of 42 tomato samples, at concentrations of 27.1 to 85.7 ug/kg, in samples of peeled canned tomatoes collected from Italian supermarkets. Of the total of 42 tested tomato samples, BPB was detected in 9 samples (21.4%). BPA and BPB were simultaneously present in 8 of the analyzed samples(1).

Bisphenol B's production and use in the manufacture of phenolic and polycarbonate resins(1,2) may result in its release to the environment through various waste streams(SRC). Bisphenol B can be released from resin linings used as corrosion inhibitors to coat cans in the food industry(2).

Occupational exposure to bisphenol B may occur through dermal contact with this compound at workplaces where bisphenol B is produced or used. Monitoring and use data indicate that the general population may be exposed to bisphenol B via ingestion of food and dermal contact with this compound or other products containing bisphenol B. (SRC)

Bisphenol B's production and use in the manufacture of phenolic and polycarbonate resins may result in its release to the environment through various waste streams. Bisphenol B can be released from resin linings used as corrosion inhibitors to coat cans in the food industry. If released to air, an estimated vapor pressure of 2.5X10-7 mm Hg at 25 °C indicates bisphenol B will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase bisphenol B will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5 hours. Particulate-phase bisphenol B will be removed from the atmosphere by wet and dry deposition. If released to soil, Bisphenol B is expected to have no mobility based up...

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/ALTERNATIVE and IN VITRO TESTS/ Endocrine disruptor chemicals (EDCs), which are predominantly present in the environment, are able to mimic or antagonise the biological activity of hormones primarily through the interaction with specific receptors. The main consequences are adverse effects on the growth and development of reproductive organs, the induction of cancer and effects on neuronal differentiation. In this study, /the researchers/ investigated the ability of certain EDCs, Bisphenol A (BPA), Bisphenol B (BPB), Bisphenol F (BPF), 4-n Nonylphenol (NP) and Octylphenol (OP), belonging to a homogeneous group of phenol origin, to interfere with specific cellular processes, namely, proliferation, by using MCF-7 breast carcinoma cells, and differentiation, by using murine bone marrow de...

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...