化合物详情

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Summary: It is concluded that under the conditions of this bioassay, 3-(chloromethyl)pyridine hydrochloride was carcinogenic in male Fischer 344 rats and B6C3F1 mice of both sexes, producing papillomas and carcinomas at the site of topical application, the stomach.

LD50 Mouse oral 316 mg/kg

The mutagenicity of halogenated pyridines was evaluated in vitro using the Salmonella typhimurium mammalian microsome test. The purpose of the study to establish an initial data base for structure/activity relationship studies. Sixteen pyridines consisting of seven chlorinated pyridines, three fluorinated pyridines, three methylated pyridines, and three chloromethyl pyridines were tested in Salmonella typhimurium (TA-97, TA-98, TA-100, and TA-102) with or without metabolic activation with rat liver S9 mix. Among the tested compounds, four were clearly mutagenic, three gave equivocal results, and nine were nonmutagenic. 2-Chloropyridine, 2,3-dichloropyridine, 2-chloromethylpyridine, and 3-chloromethylpyridine showed definite mutagenicity in at least one strain. Only 2-chloropyridine was...

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aromatic hydrocarbons and related compounds/