化合物详情

This substance may be hazardous to the environment. Special attention should be given to aquatic organisms.

ON THE PACIFIC FLOOR ALONE, THERE IS AN ESTIMATED 400 BILLION METRIC TONS ... .

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

respiratory system, central nervous system, blood, kidneys

LD50: 9 g/kg (Oral, Rat) (T26)

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. High levels of manganese may also cause damage to the reproductive system. (L228)

ACGIH Carcinogen - Not Classifiable.

Oral (L228); inhalation (L228)

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to interact with other neurotransmitters, such as GABA and glutamate. Manganese overwhelms the manganese superoxide dismutase and produce oxidative damage.... CDC-ATSDR Toxicological Profile

Chronic Inhalation: 0.0003 mg/m3 (L134)

Oral Chronic Reference Dose Reference: SURROGATE. IRIS recommends subtracting Mn dietary exposure and applying a modifying factor of 3.

2.5-5 mg/day /Total manganese/

No indication of carcinogenicity to humans (not listed by IARC).

/GENOTOXICITY/ ... Sprague-Dawley rats were exposed to a stainless steel arc welding fume for 2 hr/day in an inhalation chamber with a 1107.5 +/- 2.6 mg/cu m concentration of total suspended particulate (TSP) for 30 days. Thereafter, the total RNA was extracted from the peripheral blood mononuclear cells, the cDNA synthesized from the total RNA using the SMART PCR cDNA method, and SSH performed to select the welding-fume-exposure-regulated genes. The cDNAs identified by the SSH were then cloned into a plasmid miniprep, sequenced and the sequences analysed using the NCBI BLAST program. In the SSH cloned cDNA microarray analysis, five genes were found to increase their expression by 1.9-fold or more, including Rgs 14, which plays an important function in cellular signal transduction pathw...

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 0.04

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs o...

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 0.04

Reference: Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP