化合物详情

ONLY VERY SMALL CONCN OF TUNGSTEN...IN ATMOSPHERE...RELATED TO INDUST EMISSIONS OR...NUCLEAR FALLOUT. LEVELS...USUALLY...LESS THAN 1.5 NG/CU M IN AIR. ...ISOTOPES...PRODUCED IN NUCLEAR EXPLOSIONS ON SOME OCCASIONS IN LARGE AMT. THESE...WIDELY DISTRIBUTED IN ENVIRONMENT PRIMARILY AS TUNGSTIC OXIDE.

TUNGSTEN POISONING GENERALLY OCCURS AFTER CONTINUED EXPOSURE TO INDUST DUSTS & VAPORS IN REFINING OF TUNGSTEN OR AFTER ACCIDENTAL INGESTION OF TUNGSTATES.

The average tungsten concentration in the earth's crust is about 0.006%. Tungsten occurs naturally as tungstate, mainly in compounds such as wolframaites and scheelites. Tungsten exists in several oxidation states, 0, 2+, 3+, 4+, 5+, and 6+. The most stable is 6+ with the lower states being relatively unstable. Tungsten exist as ions in combination with one or more elements, e.g., oxygen. The production and use of tungsten compounds as catalysts (e.g., tungsten oxides and sulfides); cutting and forming tools (e.g., tungsten carbide); filaments (e.g., tungsten metal and alloys); and dyes and pigments (e.g., organic tungsten) may result in the release of tungsten to the environment through various waste streams. Only small concentrations of tungsten have been released into the atmosphere...

irritation eyes, skin, respiratory system; diffuse pulmonary fibrosis; loss of appetite, nausea, cough; blood changes

Eyes, skin, respiratory system, blood

Ingestion (L2144); inhalation (L2144); absorption (L2144)

Tungsten oxide (or tungsten trioxide: WO3) is a chemical compound containing oxygen and the transition metal tungsten. Possible health impact of WO3 nanoparticles (NPs) upon introduction into the body is of great interest. Cytotoxicity, inflammation and increased oxidative stress through reactive oxygen species (ROS) formation are prominently discussed to be relevant factors regarding the safety of small particles down to the nano-range. It has been reported that different sizes and morphologies of NPs have the potential to influence the interaction with many kind of biomolecules, including proteins, enzymes and DNA. The liver was considered as a target site for nanotoxicity due to its accumulative properties after ingestion, inhalation or absorption. (L2144) Tungsten interferes with mo... CDC-ATSDR Toxicological Profile

Oral Subchronic Chronic Reference Dose Reference: PPRTV Current

THERE ARE NO DATA AVAIL ON OCCUPATIONAL EXPOSURES TO COMPD OF TUNGSTEN WHICH INCRIMINATE THESE AS TOXIC OR HAZARDOUS AGENTS.

No indication of carcinogenicity to humans (not listed by IARC).

LD50 Rat ip 5 g/kg bw /Tungsten metal powder/

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 1

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 1