化合物详情

A patient with scalp lesions and that used selenium shampoos had a level of selenium sulfide as high as 32 ug/mL in her urine(1).

Selenium sulfide does not readily dissolve in water and would probably bind tightly to the soil(1).

... In 1976, EPA estimated that the medicinal industry generates about 700 pounds of selenium sulfide wastes annually.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2,965 workers (2,490 of these were female) were potentially exposed to selenium sulfide in the US(1).

No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity. (L1522)

Evacuation of the stomach contents should be considered in cases of acute oral ingestion. (L1712)

LD50: 138 mg/kg (Oral, Rat) (T59)

Chronic oral exposure to high concentrations of selenium compounds can produce a disease called selenosis. The major signs of selenosis are hair loss, nail brittleness, and neurological abnormalities (such as numbness and other odd sensations in the extremities). Animal studies have shown that selenium may also affect sperm production and the female reproductive cycle. (L619)

NTP Carcinogen - Reasonably anticipated to be a human carcinogen.

Oral (L619); Inhalation (L619); Dermal (L619) There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.

Selenium sulfide can be decomposed to selenium ions. Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in fo...

Chronic Oral: 0.005 mg/kg/day (L134)

Oral Chronic Reference Dose Reference: CALEPA

/OTHER TOXICITY INFORMATION/ Selenium sulfide ... /as a keratolytic agent/ appears to affect the epidermal cell turnover rate and the keratinization process.

3, not classifiable as to its carcinogenicity to humans. (L135)

LD50 Mouse oral 370 mg/kg

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 1

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 1