化合物详情

NIOSH (NOES Survey 1974) has statistically estimated that 11 workers are potentially exposed to lithium hydride in the US(1).

irritation eyes, skin; eye, skin burns; mouth, esophagus burns (if ingested); nausea; muscle twitches; mental confusion; blurred vision

Eyes, skin, respiratory system, central nervous system

LCLo (rat) = 10 mg/m3/4H

Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

inhalation, ingestion, skin and/or eye contact

/SIGNS AND SYMPTOMS/ In atmospheres containing 0.5 mg/cu m, the skin becomes inflamed and lacrimation occurs.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 862]

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In a study on rats, guinea pigs and rabbits no histopathology attributable to lithium hydride was found in the lung, liver, kidney, trachea or lymph nodes 2-5 months after exposure to about 5 mg Li/cu m for 5 days (average exposure 4 hours/day).

In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of lithium hydride might cause exacerbation of symptoms due to its irritant properties. ... Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. ... Persons with pre-existing eye conditions may be at increased risk from exposure.

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... Monitor cardiac rhythm and treat arrhythmias if necessary ... Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... Treat seizures with diazepam or lorazepam ... Use proparacaine hydroc...