化合物详情

LC50 Carp >10,000 mg/l/72 hr /Conditions of bioassay not specified/

Amorphous silica (such as fumed silica) is incorporated in a variety of food productsas anti-caking agent at levels up to 2% by weight ... also as an anti-caking agent and as an excipient in pharmaceuticals.

Amorphous silica fibers were identified as smoke constituents in three of seven area samples located near burning sugar cane fields in HawaiiAmorphous silica fibers were observed in samples collected /near/rice farming operations in California

NIOSH (NOES Survey 1981-1983) has statistically estimated that 944,731 workers (112,888 of these are female) are potentially exposed to silica crystalline quartz in the US(1). NIOSH (NOES Survey 1981-1983) has statistically estimated that 31,369 workers (2,228 of these are female) are potentially exposed to silica crystalline cristobalite in the US(1). NIOSH (NOES Survey 1981-1983) has statistically estimated that 2,042 million workers (351 of these are female) are potentially exposed to silica crystalline tridymite in the US(1). NIOSH has estimated that as many as 3.2 million workers in the United States are exposed to silica from occupations from mining and quarrying of coal and minerals, to stone cutting and construction to production of glass, ceramics, and foundry molds during sand...

irritation eyes, pneumoconiosis

Occupational studies have found that the major source of co-morbidity with silicosis is infection by Mycobacterium tuberculosis (TB).

Eyes, respiratory system

Fibrogenic - Inducing tissue injury and fibrosis (scarring).

inhalation, skin and/or eye contact

IDENTIFICATION: Quartz is a frequently occurring solid component of most natural mineral dusts. HUMAN EXPOSURE: Human exposures to quartz occur most often during occupational activities that involve the movement of earth, disturbance of silica containing products (masonry, concrete), or use or manufacture of silica containing products. Environmental exposure to ambient quartz dust can occur during natural, industrial and agricultural activities. Respirable quartz dust particles can be inhaled and deposited in the lung. There are many epidemiological studies of occupational cohorts exposed to respirable quartz dust. Silicosis, lung cancer and pulmonary tuberculosis are associated with occupational exposure to quartz dust. Statistically significant increases in deaths or cases of bronchit... CDC-ATSDR Toxicological Profile

Inhalation Chronic Reference Concentration Reference: CALEPA

IARC Monographs: Volume 68: (1997) Silica, Some Silicates, Coal Dust and para-Aramid Fibrils

LD50 Rat iv 500 mg/kg bw /Quartz (10-200 um)/

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 1

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

Fraction of Contaminant Absorbed in Gastrointestinal Tract: 1

Reference: Smith, C.D. and Nowell, L.H., 2024. Health-Based Screening Levels for evaluating water-quality data (3rd ed.). DOI:10.5066/F71C1TWP