化合物详情

Pesticide Ecotoxicity Data from EPA: 10

Skin contact can cause redness, pain, and severe skin burns. Chromic acid may cause severe burns to the eye and permanent eye damage. Severe and rapid corrosive burns of the mouth, gullet and gastrointestinal tract will result if chromic acid is swallowed. Symptoms include burning, choking, nausea, vomiting and severe pain.

The mainstay of treatment of any acid burn is copious irrigation with large amounts of tap water. To be most effective, treatment should be started immediately after exposure, preferably before arrival in the emergency department. Remove any contaminated clothing. Do not attempt to neutralize the burn with weak reciprocal chemicals (i.e. alkali for acid burns), because the heat generated from the chemical reaction may cause severe thermal injury.

LD50: 330 mg/kg (Oral, Dog) (A551)

Skin contact with chromic acid can cause redness, pain, and severe skin burns. Chromic acid may cause severe burns to the eye and permanent eye damage. Severe and rapid corrosive burns of the mouth, gullet and gastrointestinal tract will result if chromic acid is swallowed. Symptoms include burning, choking, nausea, vomiting and severe pain. Chronic exposure to low levels of chromic acid can lead to chronic exposure to hexavalent chromium. Hexavalent chromium is a known carcinogen. Chronic inhalation especially has been linked to lung cancer. Hexavalent chromium is also known to cause reproductive and developmental defects. (A12)

ACGIH Carcinogen - Confirmed Human.

Oral (L16); inhalation (L16); dermal (L16)

Chromic acid is highly corrosive and strongly oxidative. Many strong acids cause tissue burns through the denaturation of proteins and partial hydrolysis of proteins. Most proteins denature at pH values of less than 3-4. The large-scale denaturation of proteins, de-esterification of lipids and subsequent desiccation of tissues leads to chemical burns. . Symptoms include itching, bleaching or darkening of skin or tissues, blistering and burning sensations. Chromic acid also denatures proteins through inserting oxygen atoms into protein side chains. Chromic acid is also a source of chromium and especially hexavalent chromium. Hexavalent chromium compounds (including chromium trioxide, chromic acids, chromates, chlorochromates) are toxic and carcinogenic. For this reason, chromic acid oxid...

Intermediate Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.001 mg/kg/day (L134)

Inhalation Short-term Reference Concentration Reference: ATSDR Final

Severe poisoning follows the ingestion of as little as 1 to 2 g of compounds containing hexavalent chromium ion. The lethal dose is approximately 6 g.

Acceptable daily intake (ADI) value of 0.175 mg/day/man for chromium(VI). /Hexavalent chromium/

1, carcinogenic to humans. (L135)

LD100 Rat oral 350 mg/kg /From table/

Evaluation: There is sufficient evidence in humans for the carcinogenicity of chromium(VI) compounds as encountered in the chromate production, chromate pigment production and chromium plating industries. There is sufficient evidence in experimental animals for the carcinogenicity of calcium chromate, zinc chromates, strontium chromate and lead chromates. There is limited evidence in experimental animals for the carcinogenicity of chromium trioxide (chromic acid) and sodium dichromate. Overall evaluation: Chromium(VI) is carcinogenic to humans (Group 1). The Working Group made the overall evaluation on chromium(VI) compounds on the basis of the combined results of epidemiological studies, carcinogenicity studies in experimental animals, and several types of other relevant data which sup...