化合物详情

The organs of two burn patients who had been treated with fresh dressings of silver nitrate continuously for at least 6 days or every 8 hr for 30 days were analyzed. In the 66 yr old man, who had died of a brain tumor about 50 days after the 8 hr treatment was initiated, the silver concentrations in the tissues were slightly above normal: bone, 0.025 mg/kg; heart, 0.040 mg/kg; kidney, 0.140 mg/kg; and skin, 2,800 mg/kg. The second patient was an 18 yr old male, who died of respiratory complications on his 7th hospital day. Before death, the silver concentration in his urine was 0.038 mg/l and in his blood, 0.12 mg/l. There was no silver detected in his lung or brain; but the concentrations in other tissues were: heart, 0.032 mg/kg; kidney, 0.14 mg/kg; spleen, 0.23 mg/kg; liver, 0.44 mg/...

Pesticide Ecotoxicity Data from EPA: 6

The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.

IN INDUSTRY ARGYRIA FOLLOWING EXPOSURE TO SILVER OR ITS COMPOUNDS MAY BE LOCALIZED OR GENERALIZED. ... GENERALIZED ARGYRIA HAS OCCURRED ... MAINLY FROM MFR OF SILVER NITRATE & FROM ... SILVERING OF GLASS BEADS, MIRROR PLATING, DECORATION OF CHRISTMAS /ORNAMENTS/. ...

Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137, L808)

Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)

... Topical treatment /of oral tissues/ with PGF2-alpha ... decreased or inhibited the caustic response of subsequent exposure to silver nitrate ... indicating that PGF2-alpha has some cytoprotective action on the human oral mucosa. Submucosal injection of PGF2-alpha induced a mild vasodilation. ... An inflammatory response occurred after injection of PGF2-alpha and smearing of the tissue with caustics, but this disappeared in 15-30 minutes.

LD50: 23 783 ug/kg (Intraperitoneal, Mouse) (T14) LD50: 50 mg/kg (Oral, Mouse) (T20)

Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. While silver itself is not toxic, most silver salts are, and may damage the liver, kidney, and central nervous system, as well as be carcinogenic. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L808, L809, L810)

Dermatotoxin - Skin burns.

Oral (L808); inhalation (L808); dermal (L808)

Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, L808, A243,...

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)

LD50 Mouse oral 50 mg/kg

Dimercaptosuccinic acid (DMSA) provides two -SH (sulfhydryl groups) which can chelate heavy metals. ... DMSA is specific for ... silver but does not bind iron, calcium, or magnesium.