selenous acid

大鼠吸入研究表明，94%的亚硒酸沉积在肺部并在四小时内被吸收。基于这些大鼠研究的模型预测，由于吸入城市大气中的亚硒酸...，人体器官浓度不会显著增加人体负担。

该物质对水生生物有害。

化石燃料燃烧释放的硒化合物可能对人类构成潜在的吸入危害。燃烧过程中释放的最可能的硒形式是亚硒酸和元素硒。

短期高浓度硒口服暴露可能导致恶心、呕吐和腹泻。短时间暴露于高浓度元素硒或二氧化硒空气中可导致呼吸道刺激、支气管炎、呼吸困难和胃痛。对这些空气形式的长期暴露可导致呼吸道刺激、支气管痉挛和咳嗽。(L619)

毒性肺炎 - 因吸入金属烟雾或有毒气体和蒸汽引起的肺部炎症。

长期高浓度硒化合物口服暴露可导致一种称为硒中毒的疾病。硒中毒的主要症状是脱发、指甲脆性和神经系统异常（如四肢麻木和其他异常感觉）。动物研究表明，硒也可能影响精子产生和女性生殖周期。(L619)

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage...

神经系统

研究了镉、汞(Hg)和三种不同化学形式的硒(亚硒酸盐、硒代半胱氨酸和硒代蛋氨酸)对公羊精子运动能力和体外氧消耗的影响，持续4个月。10(-6)至10(-2) M浓度的镉和汞对精子有害，表现为运动能力下降和氧摄取减少。等摩尔浓度的硒作为亚硒酸盐、硒代半胱氨酸或硒代蛋氨酸在低浓度(10(-5)和10(-6) M)下可抵消镉和汞的毒性，但在较高浓度(10(-4)至10(-2) M)下则不能。... /亚硒酸盐/

口服亚慢性慢性参考剂量参考：HEAST 当前

CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on inadequate data and inadequate evidence of carcinogenicity in animals. The evidence for various selenium compounds in animal and mutagenicity studies is conflicting and difficult to interpret; however, evidnce for selenium sulfide is sufficient for a B2 (probable human carcinogen) classification . HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Inadequate.

3，对人致癌性无法分类。(L135)

慢性口服：0.005 mg/kg/天 (L134)

参考文献：DOI:10.1016/j.drudis.2016.02.015

口服(L619)；吸入(L619)；皮肤接触(L619)

亚硒酸溶于生理盐水并在孵化第4天以0.0007至0.05毫克/蛋的剂量注射入鸡胚胎。对照蛋注射等量生理盐水(0.1毫克/蛋)。使用288枚蛋。在孵化第11天，出现畸形，包括体型减小、扭曲的肢体、扭曲的颈部、内脏外翻、水肿、异位心脏和体表出血。在16个胚胎中有2个显示心脏室间隔缺损和心室壁变薄。

胃肠道吸收的污染物比例：1

胃肠道吸收的污染物比例：1