化合物详情

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2348 workers (601 of these were female) were potentially exposed to lead fluoride in the US(1).

Symptions of chronic lead poisoning include reduced cognitive abilities, nausea, abdominal pain, irritability, insomnia, metal taste in the mouth, excess lethargy or hyperactivity, chest pain, headache and, in extreme cases, seizures, comas, and death. There are also associated gastrointestinal problems, such as constipation, diarrhea, vomiting, poor appetite, weight loss, which are common in acute poisoning. (A2, L21)

Lead poisoning is usually treated with chelation therapy using DMSA, EDTA, or dimercaprol. (L21)

LD50: 3031 mg/kg (Oral, Rat) (T14)

Lead is a neurotoxin and has been known to cause brain damage and reduced cognitive capacity, especially in children. Lead exposure can result in nephropathy, as well as blood disorders such as high blood pressure and anemia. Lead also exhibits reproductive toxicity and can results in miscarriages and reduced sperm production. (L21)

ACGIH Carcinogen - Confirmed Animal.

Oral (L136); inhalation (L136); dermal (L136)

Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead has been shown to competitively inhibit calcium's binding of calmodulin, interferring with neurotransmitter release. It exhibits similar competitive inhibition at the NMDA receptor and protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Lead also affects the nervous system by impairing regulation of dopamine synthesis and blocking evoked release of acetylcholine. However, it's main mechanism of action occurs by inhibiting delta-aminolevulinic acid dehydratase, an enzyme vital in the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (...

Chronic Inhalation: 0.05 mg/m3 (L134)

/SIGNS AND SYMPTOMS/ If inhaled /dust/ will cause dizziness or loss of consciousness. If swallowed /solid/ will cause nausea, vomiting or loss of consciousness.

0.007 mg/kg (WHO) /Lead; from table/

2A, probably carcinogenic to humans. (L135)

LD50 Mouse oral 3015 mg/kg

A3; Confirmed animal carcinogen with unknown relevance to humans. /Lead, elemental, and inorganic compounds, as Pb/