化合物详情

Calcium fluoride is the most abundant naturally occuring compound of fluoride

RISK OF FLUOROSIS IN 50 WORKERS ENGAGED FOR APPROX 30 YR IN PRODN OF PHOSPHATE FERTILIZERS WHERE AMBIENT CONCN OF FLUORIDE PARTICULATES (FLUORSPAR) RANGED FORM 0.15 TO 0.62 MG/CU M IS REPORTED.

Ingestion Exposure: Nausea. Vomiting.

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The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

CLINICAL DATA INDICATE THAT THE SODIUM SALT LIES NEAR THE BORDERLINE BETWEEN TOXICITY CLASSES 4 & 5 ... ALTHOUGH LESS TOXIC IN ANIMALS, BARIUM FLUORIDE MAY BE AS TOXIC IN MAN AS THE SODIUM SALT (OR PREHAPS SLIGHTLY MORE TOXIC). CALCIUM FLUORIDE IS COMPARATIVELY BENIGN ... BECAUSE OF ITS LOW SOLUBILITY & LOW IONIZATION.

LD50 Mouse ip 2638 mg/kg

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The pathogenicity of mixed dust from a fluorite mine was studied by animal experiments and in vitro tests. Animal experiments showed that calcium fluorite can induce only a foreign body reaction in the lungs; the fibrous nodular lesions induced by the fluorite mine dust are due mainly to its silica component. It was demonstrated that either silica or the mixed dust of a fluorite mine can stimulate pulmonary alveolar macrophages to release fibrogenetic factors in vitro, but calcium fluorite cannot. It was also demonstrated that having engulfed calcium fluorite, silica, or fluorite mine mixed dust, pulmonary alveolar macrophages release an elastase-active substance. It was suggested that the emphysematous lesion seen in autopsy material of pneumoconiosis of fluorite mine workers may be ca...