化合物详情

The substance is harmful to aquatic organisms.

NIOSH (NOES Survey 1981-1983) has statistically estimated that 57,997 workers (15,249 of these were female) were potentially exposed to barium chloride in the US(1).

Ingesting excess barium may cause vomiting, abdominal cramps, diarrhea, difficulties in breathing, increased or decreased blood pressure, numbness around the face, and muscle weakness. High levels may result in changes in heart rhythm or paralysis and possibly death. (L214)

Intravenous infusion of potassium often relieves many of the symptoms of barium toxicity. (L214)

Experiments with mice indicated that atropine significantly antagonized antinociception and death induced by intracerebroventricular injection of barium chloride.

Eyes, skin, respiratory system, heart, central nervous system

LD50: 220 mg/kg (Oral, Rat) (T29) LD50: 178 mg/kg (Subcutaneous, Rat) (T46) LD50: 20 mg/kg (Intravenous, Rat)

The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. (L214)

Oral (L214); inhalation (L214)

Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. Some of these barium's effects may also be due to barium induced neuromuscular blockade and membrane depolarization. (L214)

Intermediate Oral: 0.2 mg/kg/day (L134) Chronic Oral: 0.2 mg/kg/day (L134)

Ingestion of 0.8 g may be fatal.

No indication of carcinogenicity to humans (not listed by IARC).

A4: Not classifiable as a human carcinogen. /Barium and soluble cmpd, as Ba/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or is in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of 0.9% saline (NS) or lactated Ringer's (LR) /SRP: "To keep open", minimal flow rate/. For hypotension with signs of hypovolemia, administer fluid cautiously Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Barium and Related Compounds/