化合物详情

CAS13746-89-9

分子式N4O12Zr

分子量339.24 g/mol

危化品

Physical Description | Zirconium nitrate is a white crystalline solid. It is soluble in water. It is noncombustible, but it will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Toxic oxides of nitrogen are produced in fires involving this material. It is used as a preservative.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Probable Routes of Human Exposure

NIOSH (NOES Survey 1981-1983) has statistically estimated that 268 workers (none of these were female) were potentially exposed to zirconium nitrate in the US(1). Occupational exposure to zirconium nitrate may occur through inhalation of dust and dermal contact with this compound at workplaces where zirconium nitrate is produced or used(SRC).

Interactions

Tested in vivo, zirconium nitrate was the most effective of 6 zirconium compounds in decreasing retention of (144)cerium by liver and femur of rats. None affected strontium retention by tibia or femur.

Toxicity Data

LCLo (rat) = 500 mg/m3/30 min

Adverse Effects

Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Toxicity Summary

IDENTIFICATION AND USE: Zirconium nitrate is a white hygroscopic crystal. It is used as a reagent and preservative. Also, it is used in pre-coatings applied on glass surfaces before the application of phosphor photo binder in the production of cathode-ray tubes. Zirconium nitrate has been identified as being used in hydraulic fracturing as a cross linker. HUMAN EXPOSURE AND TOXICITY: No human studies were found for this chemical. ANIMAL STUDIES: Zirconium nitrate has relatively low acute toxicity LD50 (rat oral 2290 mg/kg). Tested in vivo, zirconium nitrate was the most effective of 6 zirconium compounds in decreasing retention of (144) Cerium by liver and femur of rats. None affected strontium retention by tibia or femur. In vitro zirconium nitrate produced a slight inhibition of amyla...

Non-Human Toxicity Values

LD50 Rat oral 2290 mg/kg

Non-Human Toxicity Excerpts

/ALTERNATIVE and IN VITRO TESTS/ ... Produced a slight (10.5%) inhibition of amylase activity at 0.53 mM concentration in vitro, a 20% inhibition of yeast invertase at 0.7 mM, and a 50% inhibition of serum alkaline phosphatase at 0.9 mM, but no inhibition of trypsin at 1 mM concentration. The rather low inhibitory effects produced on these enzymes at the zirconium concentrations used indicate no specific effect of zirconium on these particular enzymes.

Antidote and Emergency Treatment

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepa...