化合物详情

EC50 Chlorella pyrenoidosa (Green algae; growth inhibition) 1.1 mg/L/96 hr; static /formulated product/

Zinc diethyldithiocarbamate is used as an accelerator in vulcanization of rubber. Dithiocarbamates are frequently present in domestic rubber goods such as gloves, clothing & contraceptive sheaths, that may cause urticaria.

Diethyldithiocarbamic acid zinc salt has been identified in rubber household and surgical gloves(1).

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)

Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)

LD50: 142 mg/kg (Oral, Mouse) (T14)

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Oral (L49); inhalation (L49); dermal (L49)

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Intermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)

/CASE REPORTS/ In Nov 1981 a 19-yr-old woman began work as a kitchen employee. In June 1982 she developed urticaria on wrists every time she washed dishes at work, where she wore cotton & Formi-rubber latex domestic gloves. Whealing began on wrists a few minutes after she began washing, & occasionally she had edema of eyelids. Symptoms lasted 0.5 hr after removal of gloves. Itching was intense, causing excoriations on arms. There were no signs of eczema. She had no history of skin disease or atopy. Immediate reactions were not observed in patch tests. In scratch chamber tests, a small piece of rubber gloves & /zinc diethyldithiocarbamate/ ZDC produced a weal greater than histamine control at 15 min. Patient used different gloves at work when test began & no urticaria appeared. ZDC seeme...

No indication of carcinogenicity to humans (not listed by IARC).

LD50 Mouse oral 142 mg/kg

Persons who have absorbed any significant amount of thiocarbamates must avoid alcoholic beverages for at least three weeks. Disposition of thiocarbamates is slow, and their inhibitory effects on enzymes are slowly reversible. /Thiocarbamates/