化合物详情

CAS14611-52-0

分子式C13H17N · HCl

分子量223.74 g/mol g/mol

危化品

Selegiline Hydrochloride is the hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (MAO) inhibitor, selegiline has the greatest affinity for type B MAO, found mainly in the brain. Selegiline is converted by MAO B to an active moiety, which binds irreversibly at the active site of the enzyme's cofactor FAD (flavin adenine dinucleotide) molecule. This prevents the oxidative deamination of catecholamines and serotonin by MAO B, and leads to an increase in these neurotransmitters' activities resulting in improved motor function. In addition, this agent may inhibit re-uptake of dopamine by the neuron and prolong dopamine activity.

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Human Toxicity Excerpts

/CASE REPORTS/ We report here the case of a patient with fluoxetine and selegiline induced serotonin syndrome, which presented as encephalopathy, generalized myoclonas, fever, stiffness and sweating, complicated with acute renal failure, rhabdomyolysis and disseminated intravascular coagulation findings. The patient died 6 days after admission. /Selegiline/

Drug Induced Liver Injury

References: DOI:10.1016/j.drudis.2016.02.015

Non-Human Toxicity Values

LD50 Rat iv 81 mg/kg

Non-Human Toxicity Excerpts

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Reproduction studies in rabbits given oral selegiline hydrochloride dosages of 5, 25, or 50 mg/kg (10, 48, or 95 times the human therapeutic dose on a mg/sq m basis) have not revealed teratogenic effects; however, the number of litters produced at the 2 highest dosage levels was lower than that recommended for assessment of teratogenic potential. An increase in total resorptions and percent postimplantation loss, and a decrease in the number of live fetuses per dam was observed at the highest dose level.

Effects During Pregnancy and Lactation

Selegiline can decrease serum prolactin in women with migraine, and in those taking neuroleptic drugs. The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.