化合物详情

IDENTIFICATION AND USE: Zirconium disulfate forms white crystals. it is used in the preparation of nickel catalyst for the hydrogenation of vegetable oil; used for flame-resistant treatment of wool fabric; as a chemical reagent, in lubricants, and tanning of leather. Zirconium sulfate has been identified as being used in hydraulic fracturing as a crosslinker. HUMAN EXPOSURE AND TOXICITY: No human studies were found at time of review. ANIMAL STUDIES: Oral administration of zirconium (fed as 5 ppm zirconium sulfate) to rats from weaning until natural death failed to influence longevity, tumor incidence, or organ-to-body-weight ratios. Intracellular concentration sites of zirconium after injection of low doses of zirconium sulfate have been studied. Results show that zirconium is uniquely...

LD50 Rat ip 175 mg/kg. /Zirconium sulfate tetrahydrate/

/IMMUNOTOXICITY/ The beryllium (Be) and zirconium (Zr) salts, BeSO4 and Zr(SO4)2, each exerted a concentration-dependent stimulation of mouse spleen cell proliferation as measured by an increase in [(3)H]thymidine incorporation into lymphocyte DNA, although the maximal response induced by Zr(SO4)4 (4-5 fold at 100-200 microM) was greater than that by BeSO4 (2-3 fold at 1-5 microM). Preincubation of splenocytes with low concentrations of BeSO4 (less than 1 microM) or a broad range of Zr(SO4)2 concentrations (2-100 microM) was also found to assist subsequent lectin (concanavalin A; ConA)-mediated lymphocyte proliferation. The results indicate that at defined concentrations Be and Zr salts can both act as lymphocyte mitogens and augment the functional responsiveness of immune cells, which...

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or l...