化合物详情

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylolpropane triacrylate, which has an estimated vapor pressure of 5.9X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethylolpropane triacrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Vapor-phase trimethylolpropane triacrylate is also degraded in the atmosphere by reaction with ozone(SRC); t...

Using a structure estimation method based on molecular connectivity indices(1), the Koc of trimethylolpropane triacrylate can be estimated to be 1510(SRC). According to a classification scheme(2), this estimated Koc value suggests that trimethylolpropane triacrylate is expected to have low mobility in soil.

AEROBIC: Trimethylolpropane triacrylate, present at 100 mg/L, reached 19% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1); however, total degradation of trimethylolpropane triacrylate was 87% over the 4-week period with the formation of the diacrylate and monoacrylate esters plus trimethylolpropane(1).

An estimated BCF of 30 was calculated in fish for trimethylolpropane triacrylate(SRC), using a log Kow of 2.75(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on exposure periods of 6 or 8 weeks in flow-through tests, the bioconcentration potential of trimethylolpropane triacrylate in carp has been classified as low (actual BCF values not reported)(4).

The Henry's Law constant for trimethylolpropane triacrylate is estimated as 6X10-10 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that trimethylolpropane triacrylate is expected to be essentially nonvolatile from water surfaces(2). Trimethylolpropane triacrylate's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur(SRC). Trimethylolpropane triacrylate's estimated vapor pressure of 5.9X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(1), suggests that volatilize from dry soil surfaces will not be important fate process(SRC); however, trimethylolpropane triacrylate is a liquid with a noticeable acrylic odor(3) suggesting some volatilization may occur(SRC).

The rate constant for the vapor-phase reaction of trimethylolpropane triacrylate with photochemically-produced hydroxyl radicals has been estimated as 3.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of trimethylolpropane triacrylate with ozone has been estimated as 5.25X10-18 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1) which corresponds to an atmospheric half-life of about 2 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.0242 L/mole-sec a...

Trimethylolpropane triacrylate's production and use as a multifunctional monomer, cross-linking agent, reactive diluent, and chemical intermediate and use in producing inks, coatings, varnishes, paints and resins(1) may result in its release to the environment through various waste streams(SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 5,274 workers (809 of these were female) were potentially exposed to trimethylolpropane triacrylate in the US(1). Occupational exposure to trimethylolpropane triacrylate may occur through inhalation and dermal contact with this compound at workplaces where trimethylolpropane triacrylate is produced or used(SRC). Workers involved in the manufacturing, processing, product handling, and application of trimethylolpropane triacrylate are at risk of exposure(2). A potential exists for widespread exposure of consumers through the use of trimethylolpropane triacrylate in products such as latex paints and furniture and floor polishes(2).

Trimethylolpropane triacrylate's production and use as a multifunctional monomer, cross-linking agent, reactive diluent, and chemical intermediate and use in producing inks, coatings, varnishes, paints and resins may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 5.9X10-4 mm Hg at 25 °C indicates trimethylolpropane triacrylate will exist solely as a vapor phase in the atmosphere. Vapor-phase trimethylolpropane triacrylate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 11 hours. Vapor-phase trimethylolpropane triacrylate will also be degraded in the atmosphere by reaction with ozone; the half-life for this r...

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

Summary: Dermal application of trimethylolpropane triacrylate for 2 years resulted in increased incidences of nonneoplastic lesions in the skin (site of application) of male and female rats and mice.

LD50 Rat oral 5190 mg/kg

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use...