化合物详情

CAS15686-71-2

分子式C16H17N3O4S

分子量347.38 g/mol g/mol

危化品

Cephalexin is a semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract. It has a role as an antibacterial drug. It is a cephalosporin, a semisynthetic derivative and a beta-lactam antibiotic allergen. It is a conjugate acid of a cephalexin(1-).

科学粮草官-词典编辑部，修订于：2026-07-06

Toxicity

Adverse Effects

* Probenecid: Coadministration of cephalexin with probenecid is not recommended as it may inhibit the renal excretion of cephalexin. Studies have shown that probenecid can extend and flatten the plasma concentration–time curve of cephalexin, thereby increasing the likelihood of achieving optimal pharmacokinetic and pharmacodynamic targets. However, the simultaneous use of cephalexin and probenecid may benefit specific patient populations.

Toxicity Summary

In the event of an overdose, it is advisable to implement general supportive measures. However, the effectiveness of interventions such as charcoal hemoperfusion, forced diuresis, peritoneal dialysis, and hemodialysis in treating cephalexin overdose has not been established yet. To obtain the most up-to-date protocol for managing cephalexin overdose, it is recommended to contact the local drug poison center.

Drug Induced Liver Injury

References: DOI:10.1016/j.drudis.2019.09.022

Non-Human Toxicity Values

LD50 RAT INTRAPERITONEAL GREATER THAN 3.7 G/KG /MONOHYDRATE/

Antidote and Emergency Treatment

CEPHALEXIN IS EFFICIENTLY REMOVED FROM CIRCULATION BY HEMODIALYSIS OR PERITONEAL DIALYSIS.

Effects During Pregnancy and Lactation

Studies have not been done to see if cephalexin could affect male fertility (ability to get partner pregnant) or increase the chance of birth defects above the background risk. Some infections, such as Staph or E.coli, might affect male fertility. In general, exposures that fathers or sperm donors have are unlikely to increase risks to a pregnancy. For more information, please see the MotherToBaby fact sheet Paternal Exposures at https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/.