化合物详情

Most of the adverse events reported in patients with mastocytosis have been transient and can be symptoms of the disease. The most frequently reported adverse events in patients with mastocytosis who received oral cromolyn sodium solution in clinical studies were headache, diarrhea, pruritus, nausea, myalgia, abdominal pain, rash, and irritability. In addition, adverse events associated with oral solution include vomiting, constipation, erythema, photosensitivity, urticaria, and angioedema. Other reported adverse events, including reports of dyspepsia, constipation, glossitis, flatulence, stomatitis, vomiting, dysphagia, and esophagospasm, in clinical studies of patients with comorbid conditions as well as postmarketing patient experience were infrequent; attribution to cromolyn could n...

In the event of a hypersensitivity reaction, patients should receive treatment with antihistamines with or without beta-agonists, corticosteroids, and epinephrine. In the case of a severe hypersensitivity reaction, oxygen, antihistamines, epinephrine, corticosteroids, electroencephalogram monitoring, and intravenous fluids should be administered. No specific labs or testing are necessary unless indicated. Management of mild to moderate toxicity is symptomatic and supportive. The clinician should correct any significant fluid and electrolyte abnormalities in patients with vomiting or diarrhea. Severe toxicity is not expected following an overdose, which should be managed with symptomatic and supportive treatment.

◉ Effects on Lactation and Breastmilk